Follow-up of T-cell diversity after CBT and genoidentical BMT
Time point . | CBT . | BMT . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Poly, % . | Skew, % . | Neg, % . | Peaks, no. . | No. . | Poly, % . | Skew, % . | Neg, % . | Peaks, no. . | No. . | |
Before transplantation | 49 | 16 | 35 | 154 | 5 | 65 | 23 | 12 | 189 | 8 |
2-6 mo | 31 | 36 | 33 | 129 | 4 | 35 | 49 | 15 | 149 | 10 |
1 y | 35 | 50 | 15 | 167 | 5 | 41 | 51 | 8 | 175 | 15 |
2 y or more | 893-150 | 83-151 | 3 | 200 | 8 | 563-150 | 363-151 | 8 | 216 | 15 |
Time point . | CBT . | BMT . | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Poly, % . | Skew, % . | Neg, % . | Peaks, no. . | No. . | Poly, % . | Skew, % . | Neg, % . | Peaks, no. . | No. . | |
Before transplantation | 49 | 16 | 35 | 154 | 5 | 65 | 23 | 12 | 189 | 8 |
2-6 mo | 31 | 36 | 33 | 129 | 4 | 35 | 49 | 15 | 149 | 10 |
1 y | 35 | 50 | 15 | 167 | 5 | 41 | 51 | 8 | 175 | 15 |
2 y or more | 893-150 | 83-151 | 3 | 200 | 8 | 563-150 | 363-151 | 8 | 216 | 15 |
Mann-Whitney U test. All values are presented as mean.
Poly indicates polyclonal BV families; skew, disturbed BV families; neg, negative BV families; and peaks, total number of different β-chain CDR3 sizes in the whole TCRBV repertoire in patients undergoing CBT and BMT.
P = .0021.
P = .0017.