Enumeration of human tBOECs in murine marrow and spleen
| Cell dose group . | N . | Time (d) . | tBOECs (% nucleated cells) . | |
|---|---|---|---|---|
| Marrow . | Spleen . | |||
| 10 × 104 | 2 | 28 | 0.7, 1.0 | 1.3, 1.6 |
| 20 × 104 | 1 | 9 | 0.02 | NA |
| 2 | 156 | 3.0, 5.2 | 2.4, 1.6 | |
| 40 × 104 | 1 | 156 | 4.8 | 3.6 |
| Cell dose group . | N . | Time (d) . | tBOECs (% nucleated cells) . | |
|---|---|---|---|---|
| Marrow . | Spleen . | |||
| 10 × 104 | 2 | 28 | 0.7, 1.0 | 1.3, 1.6 |
| 20 × 104 | 1 | 9 | 0.02 | NA |
| 2 | 156 | 3.0, 5.2 | 2.4, 1.6 | |
| 40 × 104 | 1 | 156 | 4.8 | 3.6 |
Five animals used for this enumeration were from the formal FVIII level study (Table 2, Figure 2) (2 killed at 28 days and 3 killed at 156 days). We also included an animal killed at 9 days after tBOEC administration; this animal was not included in the formal FVIII study because no baseline FVIII was available for it.
NA indicates not available.