Cytokine production in patients with adult T-cell leukemia
| Case . | Hypercalcemia . | BM Invasion . | Serum M-CSF (pg/mL) . | Serum PTHrP (pmol/L) . | Serum TNF-α (pg/mL) . | RANKL/ GAPDH . | OPG/ GAPDH . | PTHrP/ GAPDH . | M-CSF/ GAPDH . | TNF-α/ GAPDH . |
|---|---|---|---|---|---|---|---|---|---|---|
| PBMC | 0 | 0 | 20 | 20 | 108 | |||||
| PHA-blast | 19 | 66 | 12 | 56 | 90 | |||||
| 1 | + | ND | 2 992 | 276 | 28 | 103 | 0 | 54 | 24 | 85 |
| 2 | + | ND | 12 123 | 900 | 9 | 228 | 0 | 143 | 8 | 75 |
| 3 | + | + | 2 692 | 209 | 0 | 332 | 212 | 487 | 287 | 84 |
| 4 | + | + | 4 882 | 251 | 0 | 119 | 91 | 115 | 127 | 31 |
| 5 | + | ND | 2 713 | 223 | 0 | 188 | 53 | 302 | 29 | 23 |
| 6 | + | + | 1 478 | 290 | 0 | 63 | 0 | 117 | 0 | 14 |
| 7 | + | ND | 1 409 | 7 700 | 0 | 33 | 0 | 102 | 20 | 5 |
| 8 | + | + | 9 684 | 1 160 | 0 | 0 | 0 | 275 | 154 | 30 |
| 9 | − | ND | 833 | 42 | 0 | 5 | 0 | 71 | 0 | 38 |
| 10 | − | + | 5 231 | 253 | 0 | 0 | 0 | 75 | 21 | 84 |
| 11 | − | ND | 3 336 | 28 | 0 | 6 | 0 | 124 | 40 | 105 |
| 12 | − | ND | 8 245 | 199 | 9 | 0 | 0 | 54 | 0 | 0 |
| 13 | − | ND | 3 716 | 99 | 0 | 2 | 0 | 222 | 30 | 85 |
| 14 | − | ND | 1 413 | 156 | 0 | 2 | 0 | 101 | 16 | 49 |
| 15 | − | ND | 287 | 39 | 0 | 0 | 0 | 130 | 33 | 30 |
| Case . | Hypercalcemia . | BM Invasion . | Serum M-CSF (pg/mL) . | Serum PTHrP (pmol/L) . | Serum TNF-α (pg/mL) . | RANKL/ GAPDH . | OPG/ GAPDH . | PTHrP/ GAPDH . | M-CSF/ GAPDH . | TNF-α/ GAPDH . |
|---|---|---|---|---|---|---|---|---|---|---|
| PBMC | 0 | 0 | 20 | 20 | 108 | |||||
| PHA-blast | 19 | 66 | 12 | 56 | 90 | |||||
| 1 | + | ND | 2 992 | 276 | 28 | 103 | 0 | 54 | 24 | 85 |
| 2 | + | ND | 12 123 | 900 | 9 | 228 | 0 | 143 | 8 | 75 |
| 3 | + | + | 2 692 | 209 | 0 | 332 | 212 | 487 | 287 | 84 |
| 4 | + | + | 4 882 | 251 | 0 | 119 | 91 | 115 | 127 | 31 |
| 5 | + | ND | 2 713 | 223 | 0 | 188 | 53 | 302 | 29 | 23 |
| 6 | + | + | 1 478 | 290 | 0 | 63 | 0 | 117 | 0 | 14 |
| 7 | + | ND | 1 409 | 7 700 | 0 | 33 | 0 | 102 | 20 | 5 |
| 8 | + | + | 9 684 | 1 160 | 0 | 0 | 0 | 275 | 154 | 30 |
| 9 | − | ND | 833 | 42 | 0 | 5 | 0 | 71 | 0 | 38 |
| 10 | − | + | 5 231 | 253 | 0 | 0 | 0 | 75 | 21 | 84 |
| 11 | − | ND | 3 336 | 28 | 0 | 6 | 0 | 124 | 40 | 105 |
| 12 | − | ND | 8 245 | 199 | 9 | 0 | 0 | 54 | 0 | 0 |
| 13 | − | ND | 3 716 | 99 | 0 | 2 | 0 | 222 | 30 | 85 |
| 14 | − | ND | 1 413 | 156 | 0 | 2 | 0 | 101 | 16 | 49 |
| 15 | − | ND | 287 | 39 | 0 | 0 | 0 | 130 | 33 | 30 |
BM indicates bone marrow; M-CSF, macrophage colony-stimulating factor; PTHrP, parathyroid hormone-related protein; TNF-α, tumor necrosis factor α; RANKL, receptor activator of nuclear factor ligand; GAPDH, glyceroldehydes-3-phosphate dehydrogenase; OPG, osteoprotegerin; PBMC, peripheral blood mononuclear cell; PHA, phytohemagglutin; and ND, not determined.