Table 2. ET-1 alters kinetic parameters... | American Society of Hematology

Table 2.

ET-1 alters kinetic parameters of Gardos channel in AA and SS erythrocytes

Subjects	Control		ET-1
Subjects	V_max mmol/10¹³ cell per min	K_0.5 μM	V_max mmol/10¹³cell per min	K_0.5 μM
AA	0.71 ± 0.14	1.21 ± 0.66	1.06 ± 0.05^†	0.63 ± 0.14^†
SS	1.49 ± 0.24^*	0.460 ± 0.03^*	2.15 ± 0.01^†	0.21 ± 0.01^*,^†

Subjects	Control		ET-1
Subjects	V_max mmol/10¹³ cell per min	K_0.5 μM	V_max mmol/10¹³cell per min	K_0.5 μM
AA	0.71 ± 0.14	1.21 ± 0.66	1.06 ± 0.05^†	0.63 ± 0.14^†
SS	1.49 ± 0.24^*	0.460 ± 0.03^*	2.15 ± 0.01^†	0.21 ± 0.01^*,^†

Kinetics parameters were estimated from the best fitting of experimental points using nonlinear sigmoid regression analysis. Values are mean ± SE of 3 experiments in duplicate determinations. ET-1, 500 nM.

P < .045 (AA vs SS).

†

P < .033 (paired t test: control vs ET-1).

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