P values from likelihood ratio test for adding cell-type variable to the “base model” appropriate to each clinical outcome
Cell dose/model4-150 . | P4-151 . | ||||
---|---|---|---|---|---|
Engraftment neutrophil/platelet . | Acute GVHD . | Extensive chronic GVHD . | Survival . | Relapse . | |
CD34 | |||||
Continuous | .19/.02 | .96 | .06 | .48 | .23 |
Log | .03/.01 | .96 | .01 | .27 | .14 |
Quartiles | .13/.15 | .45 | .02 | .53 | .36 |
CD3 | |||||
Continuous | .63/.83 | .96 | .87 | .41 | .88 |
Log | .47/.50 | .81 | .77 | .70 | .55 |
Quartiles | .13/.19 | .82 | .44 | .39 | .53 |
CD14 | |||||
Continuous | .31/.77 | .74 | .82 | .93 | .79 |
Log | .48/.96 | .89 | .73 | .59 | .45 |
Quartiles | .50/.95 | .17 | .75 | .50 | .53 |
CD14 to CD3 ratio | |||||
Continuous | .73/.91 | .85 | .82 | .11 | .46 |
Quartiles | .15/.43 | .92 | .89 | .78 | .82 |
Cell dose/model4-150 . | P4-151 . | ||||
---|---|---|---|---|---|
Engraftment neutrophil/platelet . | Acute GVHD . | Extensive chronic GVHD . | Survival . | Relapse . | |
CD34 | |||||
Continuous | .19/.02 | .96 | .06 | .48 | .23 |
Log | .03/.01 | .96 | .01 | .27 | .14 |
Quartiles | .13/.15 | .45 | .02 | .53 | .36 |
CD3 | |||||
Continuous | .63/.83 | .96 | .87 | .41 | .88 |
Log | .47/.50 | .81 | .77 | .70 | .55 |
Quartiles | .13/.19 | .82 | .44 | .39 | .53 |
CD14 | |||||
Continuous | .31/.77 | .74 | .82 | .93 | .79 |
Log | .48/.96 | .89 | .73 | .59 | .45 |
Quartiles | .50/.95 | .17 | .75 | .50 | .53 |
CD14 to CD3 ratio | |||||
Continuous | .73/.91 | .85 | .82 | .11 | .46 |
Quartiles | .15/.43 | .92 | .89 | .78 | .82 |
The non-cell-type variables such as patient age at transplantation, patient/donor sex, patient/donor cytomegalovirus serostatus, risk of disease, use of total body irradiation for conditioning, presence of major ABO mismatch, and graft-versus-host disease (GVHD) prophylaxis if significantly or suggestively associated with outcome, were used to create a “base” model for each outcome. Each cell-type variable was then added to assess the improvement to the base model.
Each cell-type variable was modeled as a continuous variable, a log-transformed variable, or according to quartiles.
P value estimated by the likelihood ratio test.