Table 4.

P values from likelihood ratio test for adding cell-type variable to the “base model” appropriate to each clinical outcome

Cell dose/model4-150P4-151
Engraftment neutrophil/plateletAcute GVHDExtensive chronic GVHDSurvivalRelapse
CD34      
 Continuous .19/.02 .96 .06 .48 .23 
 Log .03/.01 .96 .01 .27 .14 
 Quartiles .13/.15 .45 .02 .53 .36 
CD3      
 Continuous .63/.83 .96 .87 .41 .88 
 Log .47/.50 .81 .77 .70 .55 
 Quartiles .13/.19 .82 .44 .39 .53 
CD14      
 Continuous .31/.77 .74 .82 .93 .79 
 Log .48/.96 .89 .73 .59 .45 
 Quartiles .50/.95 .17 .75 .50 .53  
CD14 to CD3 ratio      
 Continuous .73/.91 .85 .82 .11 .46 
 Quartiles .15/.43 .92 .89 .78 .82 
Cell dose/model4-150P4-151
Engraftment neutrophil/plateletAcute GVHDExtensive chronic GVHDSurvivalRelapse
CD34      
 Continuous .19/.02 .96 .06 .48 .23 
 Log .03/.01 .96 .01 .27 .14 
 Quartiles .13/.15 .45 .02 .53 .36 
CD3      
 Continuous .63/.83 .96 .87 .41 .88 
 Log .47/.50 .81 .77 .70 .55 
 Quartiles .13/.19 .82 .44 .39 .53 
CD14      
 Continuous .31/.77 .74 .82 .93 .79 
 Log .48/.96 .89 .73 .59 .45 
 Quartiles .50/.95 .17 .75 .50 .53  
CD14 to CD3 ratio      
 Continuous .73/.91 .85 .82 .11 .46 
 Quartiles .15/.43 .92 .89 .78 .82 

The non-cell-type variables such as patient age at transplantation, patient/donor sex, patient/donor cytomegalovirus serostatus, risk of disease, use of total body irradiation for conditioning, presence of major ABO mismatch, and graft-versus-host disease (GVHD) prophylaxis if significantly or suggestively associated with outcome, were used to create a “base” model for each outcome. Each cell-type variable was then added to assess the improvement to the base model.

F4-150

Each cell-type variable was modeled as a continuous variable, a log-transformed variable, or according to quartiles.

F4-151

P value estimated by the likelihood ratio test.

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