Serum DNR and DNR-ol concentrations (ng/mL) by assigned treatment and day of measurement
| Variable . | AraC-DNR . | AraC-DNR + CsA . | P6-150 . | ||||
|---|---|---|---|---|---|---|---|
| Median . | Range . | N . | Median . | Range . | N . | ||
| DNR d 9 | 11.8 | < 10 -348.6 | 62 | 23.1 | < 10 -609.2 | 60 | .0026 |
| DNR-ol d 9 | 51.1 | < 5 -647.5 | 62 | 201.4 | 23.7 -760.3 | 64 | < .0001 |
| DNR d 10 | < 10 | < 10 -521.7 | 58 | < 10 | < 10 -196.0 | 63 | .0005 |
| DNR-ol d 10 | 17.1 | 5.0 -542.4 | 60 | 57.4 | < 10 -987.5 | 65 | < .0001 |
| Variable . | AraC-DNR . | AraC-DNR + CsA . | P6-150 . | ||||
|---|---|---|---|---|---|---|---|
| Median . | Range . | N . | Median . | Range . | N . | ||
| DNR d 9 | 11.8 | < 10 -348.6 | 62 | 23.1 | < 10 -609.2 | 60 | .0026 |
| DNR-ol d 9 | 51.1 | < 5 -647.5 | 62 | 201.4 | 23.7 -760.3 | 64 | < .0001 |
| DNR d 10 | < 10 | < 10 -521.7 | 58 | < 10 | < 10 -196.0 | 63 | .0005 |
| DNR-ol d 10 | 17.1 | 5.0 -542.4 | 60 | 57.4 | < 10 -987.5 | 65 | < .0001 |
Two-tailed P based on Wilcoxon test with drug concentration as a continuous variable censored at lower limits of detection (10 and 5 ng/mL for DNR and DNR-ol, respectively).