Multivariate modeling
Outcome . | RR with IFN4-150 . | 95% CI . | P . |
---|---|---|---|
Overall survival | 0.99 | 0.80-1.24 | .95 |
Leukemia-free survival | 1.14 | 0.92-1.42 | .24 |
Nonrelapse mortality | 1.03 | 0.82-1.30 | .80 |
Engraftment | 0.92 | 0.78-1.08 | .30 |
Hematologic relapse | 1.16 | 0.66-2.03 | .62 |
Acute GVHD | 1.10 | 0.93-1.31 | .27 |
Chronic GVHD | 0.94 | 0.76-1.18 | .62 |
Outcome . | RR with IFN4-150 . | 95% CI . | P . |
---|---|---|---|
Overall survival | 0.99 | 0.80-1.24 | .95 |
Leukemia-free survival | 1.14 | 0.92-1.42 | .24 |
Nonrelapse mortality | 1.03 | 0.82-1.30 | .80 |
Engraftment | 0.92 | 0.78-1.08 | .30 |
Hematologic relapse | 1.16 | 0.66-2.03 | .62 |
Acute GVHD | 1.10 | 0.93-1.31 | .27 |
Chronic GVHD | 0.94 | 0.76-1.18 | .62 |
Lower weight at time of transplantation, lack of additional cytogenetic abnormalities, CMV seronegativity in patient and donor, Caucasian race, and more recent year of transplantation were associated with better survival and were included in the final models. All forms of acute and chronic GVHD were included. Conclusions were identical when the analysis was limited to grades II-IV or III-IV acute GVHD or extensive chronic GVHD.