Dose response of IL-18 on hematologic effect
| Treatment . | Serum IL-18 (ng/mL) . | WBC (counts/μL) . | Lymphocyte (%) . | Neutrophil (%) . | Eosinophil (%) . |
|---|---|---|---|---|---|
| Phosphate buffered saline | Not detected | 2856 ± 179.04 | 85.10 ± 2.21 | 10.90 ± 1.66 | 0.70 ± 0.25 |
| (n = 5) | (n = 5) | (n = 5) | (n = 5) | ||
| IL-18 (2.0 μg/mouse/day) | 201.61 ± 14.84* | 2260 ± 156.46† | 66.90 ± 2.59‡ | 26.70 ± 2.381-153 | 3.60 ± 0.681-153 |
| (n = 3) | (n = 5) | (n = 5) | (n = 5) | (n = 5) | |
| IL-18 (0.6 μg/mouse/day) | 79.72 ± 3.95* | 2229 ± 86.70NS | 78.67 ± 1.74NS | 16.50 ± 3.00NS | 1.33 ± 0.17NS |
| (n = 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) | |
| IL-18 (0.2 μg/mouse/day) | 22.47 ± 3.10 | 2240 ± 105.03NS | 83.00 ± 1.73NS | 12.92 ± 2.08NS | 1.00 ± 0.29NS |
| (n = 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) |
| Treatment . | Serum IL-18 (ng/mL) . | WBC (counts/μL) . | Lymphocyte (%) . | Neutrophil (%) . | Eosinophil (%) . |
|---|---|---|---|---|---|
| Phosphate buffered saline | Not detected | 2856 ± 179.04 | 85.10 ± 2.21 | 10.90 ± 1.66 | 0.70 ± 0.25 |
| (n = 5) | (n = 5) | (n = 5) | (n = 5) | ||
| IL-18 (2.0 μg/mouse/day) | 201.61 ± 14.84* | 2260 ± 156.46† | 66.90 ± 2.59‡ | 26.70 ± 2.381-153 | 3.60 ± 0.681-153 |
| (n = 3) | (n = 5) | (n = 5) | (n = 5) | (n = 5) | |
| IL-18 (0.6 μg/mouse/day) | 79.72 ± 3.95* | 2229 ± 86.70NS | 78.67 ± 1.74NS | 16.50 ± 3.00NS | 1.33 ± 0.17NS |
| (n = 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) | |
| IL-18 (0.2 μg/mouse/day) | 22.47 ± 3.10 | 2240 ± 105.03NS | 83.00 ± 1.73NS | 12.92 ± 2.08NS | 1.00 ± 0.29NS |
| (n = 3) | (n = 3) | (n = 3) | (n = 3) | (n = 3) |
The numbers of white blood cells (WBC), lymphocytes, neutrophils, and eosinophils are shown as a mean ± SE of 5 or 3 mice immediately after 5 weeks of treatment with respective doses of IL-18. Serum IL-18 concentrations are shown as a mean ± SE of 3 mice immediately after 5 weeks of IL-18 treatment.
NS indicates not significant.
P < .01, compared with IL-18 (0.2 μg/mouse/day) (Dunnett test for multiple comparison).
P < .05.
P < .001, compared with PBS.
P < .01, compared with PBS.