Phenotypic properties of tetramer+ CD8 T cells
| Cell marker . | HIV-1 tetramer+ cells . | EBV and CMV tetramer+ cells . |
|---|---|---|
| CD3ζ | − | − |
| CD28 | − | − |
| NKRs | ? | ? |
| CD62L | − | − |
| CD45RA | − | ± to + |
| CCR7 | − | − |
| CD27 | + | − |
| GzmA | + | + |
| Perforin | − to ± | − to ± to + |
| Bcl-2 | + | ? |
| Cell marker . | HIV-1 tetramer+ cells . | EBV and CMV tetramer+ cells . |
|---|---|---|
| CD3ζ | − | − |
| CD28 | − | − |
| NKRs | ? | ? |
| CD62L | − | − |
| CD45RA | − | ± to + |
| CCR7 | − | − |
| CD27 | + | − |
| GzmA | + | + |
| Perforin | − to ± | − to ± to + |
| Bcl-2 | + | ? |
The phenotypic properties of the majority of HIV-specific CD8 T cells are compared with those for other chronic viral infections. Data are a composite from published6,8,28,106,107,111 150 and unpublished (P.S., G. Chen, and J.L., March 2001) studies.
EBV indicates Epstein-Barr virus; CMV, cytomegalovirus; NKR, natural killer cell-inhibitory receptor; GzmA, granzyme A; ?, not known.