Table 2. Baseline and maximum platelet... | American Society of Hematology

Table 2.

Baseline and maximum platelet count by treatment group

	Placebo (n = 70 cycles)	PEG-rHuMGDF 1 μg/kg (n = 23 cycles)	PEG-rHuMGDF 3 μg/kg (n = 23 cycles)	P
Baseline, × 10⁹/L^*
Median	230	230	227	NS
Range	165-366	170-296	161-384
Maximum, × 10⁹/L^†
Median	248	366	602	< .001
Range	180-386	231-542	438-901
Maximum fold change from baseline
Median	1.1	1.7	2.7	< .001
Range	1.0-1.8	1.1-2.4	2.1-3.6
Category of maximum platelet count, × 10⁹/L^‡
Less than 450	70 (100)	18 (78)	1 (4)
450-750	0 (0)	5 (22)	15 (65)	< .001
More than 750	0 (0)	0 (0)	7 (30)

	Placebo (n = 70 cycles)	PEG-rHuMGDF 1 μg/kg (n = 23 cycles)	PEG-rHuMGDF 3 μg/kg (n = 23 cycles)	P
Baseline, × 10⁹/L^*
Median	230	230	227	NS
Range	165-366	170-296	161-384
Maximum, × 10⁹/L^†
Median	248	366	602	< .001
Range	180-386	231-542	438-901
Maximum fold change from baseline
Median	1.1	1.7	2.7	< .001
Range	1.0-1.8	1.1-2.4	2.1-3.6
Category of maximum platelet count, × 10⁹/L^‡
Less than 450	70 (100)	18 (78)	1 (4)
450-750	0 (0)	5 (22)	15 (65)	< .001
More than 750	0 (0)	0 (0)	7 (30)

NS indicates nonsignificant.

Baseline platelet count taken as the day 1 value of each cycle.

Maximum platelet count after day 1 and prior to apheresis.

Number (%) of donors with the indicated maximum platelet count.