Summary of effect of chronic graft-versus-host disease on outcomes
| Outcome . | Low-risk chronic GVHD, HR (95% CI) . | P . | High-risk chronic GVHD, HR (95% CI) . | P . |
|---|---|---|---|---|
| Relapse | 0.6 (0.2-1.6) | .3 | 0.6 (0.1-2.4) | .4 |
| Overall mortality | 1.4 (0.6-3.2) | .4 | 6.6 (3.5-12.4) | < .001 |
| Treatment failure6-150 | 1.7 (0.8-3.3) | .1 | 5.2 (2.9-9.4) | < .001 |
| Outcome . | Low-risk chronic GVHD, HR (95% CI) . | P . | High-risk chronic GVHD, HR (95% CI) . | P . |
|---|---|---|---|---|
| Relapse | 0.6 (0.2-1.6) | .3 | 0.6 (0.1-2.4) | .4 |
| Overall mortality | 1.4 (0.6-3.2) | .4 | 6.6 (3.5-12.4) | < .001 |
| Treatment failure6-150 | 1.7 (0.8-3.3) | .1 | 5.2 (2.9-9.4) | < .001 |
Hazard ratio (95% CI) at 18 months is in comparison with no chronic GVHD, when chronic GVHD is entered as a time-dependent covariate and there is adjustment for disease status at the time of transplantation.
For abbreviations, see footnote to Table 2.
Treatment failure defined as relapse or death without relapse.