Genes whose expression is up-regulated in mantle cell lymphoma compared to hyperplastic lymph nodes as analyzed by oligonucleotide microarray
| Gene . | Access . | Map . | Description . | Change . |
|---|---|---|---|---|
| Transcription factors | ||||
| AF10 | U13948 | 10p12 | ALL1 fused gene from chromosome 10 | |
| AP2α | M61156 | 6p22.3 | Transcription factor AP2α | > 10 |
| ATF1 | X55544 | 12q13 | Activating transcription factor | > 10 |
| C/EBPγ | U20240 | CCAAT/enhancer binding protein γ | > 10 | |
| DP2 | L40386 | E2F dimerization partner DP2 | > 10 | |
| E2F5 | U15642 | E2F transcription factor 5 | > 10 | |
| JUN | U65928 | 1p32 | V-jun avian sarcoma virus oncogene homolog | 8 |
| MYBL2 | X13293 | 20q13.1 | V-myb avian myeloblastosis viral oncogene | |
| MYC | M13929 | 8q24.12 | Avian myelocytomatosis viral oncogene | > 10 |
| PBX2 | X59842 | 6p21.3 | Pre-B-cell transcription factor 2 | > 10 |
| TAF2 | X84003 | TBP associated factor, RNA polymerase 2 | > 10 | |
| TAF2D | X95525 | 10q24 | 100-kd subunit of Pol II | > 10 |
| TBP | X54993 | 6q27 | TATA box binding protein | 6 |
| YES1 | M15990 | 18p11.31 | Yamaguchi sarcoma virual oncogene | > 10 |
| Cell-cycle–related genes | ||||
| CCND1 | X59798 | 11q13 | Cyclin D1 | > 10 |
| CCNG2 | U47414 | 4 | Cyclin G2 | > 10 |
| CDC8 | L16991 | Deoxythymidylate kinase | > 10 | |
| CDK4 | U37022 | 12q14 | Cyclin-dependent kinase 4 | > 10 |
| CKS1 | X54941 | 8q21 | CDC28 protein kinase 1 | > 10 |
| MDM2 | U33203 | 12q14.3 | Homolog of mouse double minute 2 | > 10 |
| RB1 | L49209 | 13q14.1 | Retinoblastoma, exon 4 | > 10 |
| RBBP2 | S66431 | 12p11 | Retinoblastoma-binding protein 2 | > 10 |
| RBBP5 | X85134 | 1q32 | Retinoblastoma-binding protein 5 | > 10 |
| SKP2 | U33761 | 5p13 | S-phase kinase-associated protein 2 | > 10 |
| Growth factors/receptors | ||||
| ICSBP1 | M91196 | Interferon consensus sequence binding protein 1 | > 10 | |
| IFNA16 | M27318 | 9q22 | Interferon alpha 16 | 6 |
| IFNA201 | K01900 | 9q22 | Interferon alpha-201 | > 10 |
| IL-1R1 | M27492 | 2q12 | Interleukin-1 receptor, type 1 | > 10 |
| IL-3 | M20137 | 5q23 | Interleukin-3 | > 10 |
| IL-8 | M28130 | 4q12 | Interleukin-8 | > 10 |
| IL-13 | U31120 | 5q31 | Interleukin-13 | > 10 |
| IL-13RA1 | Y10659 | Chr X | Interleukin-13 receptor, alpha 1 | > 10 |
| IL-18 | D49950 | 11q22.2 | Interleukin-18 | > 10 |
| ILF3 | U10324 | Interleukin enhancer binding factor 3 | > 10 | |
| LIFR | X61615 | 5p13 | Leukemia inhibitory factor receptor | 4 |
| Signal proteins and others | ||||
| BCL2 | U15173 | Oncogene B-cell leukemia 2 | > 10 | |
| BLK | S76617 | 8p23 | B lymphoid tyrosine kinase | 6 |
| FLI1 | M98833 | 11q24.1 | Friend leukemia virus integration 1 | 4 |
| H1F0 | X03473 | 22q13.1 | H1 histone family, member 0 | > 10 |
| H2BFQ | M60571 | 1q21 | H2B histone family, member Q | > 10 |
| NCK1 | X17576 | 3q21 | Melanoma NCK protein | > 10 |
| NRAS | X02751 | 1p13 | Neuroblastoma RAS viral oncogene homolog | > 10 |
| OGR1 | U48405 | 14q31 | Ovarian cancer G protein-coupled receptor 1 | 6 |
| PRKCB1 | X06318 | 16p12 | Protein kinase C, beta 1 | 8 |
| PRKM8 | U35005 | Protein kinase mitogen-activated 8 (JNK1) | > 10 | |
| RAB2 | M28213 | RAS-associated protein 2 | 8 | |
| RAB9 | U44103 | RAS-associated protein 9 | > 10 | |
| REL | X75042 | 2p13 | V-rel avian reticuloendotheliosis viral oncogene | 6 |
| RXRG | U38480 | 1q22 | Retinoic X receptor gamma | > 10 |
| STAF50 | X82200 | Interferon inducible gene | 8 |
| Gene . | Access . | Map . | Description . | Change . |
|---|---|---|---|---|
| Transcription factors | ||||
| AF10 | U13948 | 10p12 | ALL1 fused gene from chromosome 10 | |
| AP2α | M61156 | 6p22.3 | Transcription factor AP2α | > 10 |
| ATF1 | X55544 | 12q13 | Activating transcription factor | > 10 |
| C/EBPγ | U20240 | CCAAT/enhancer binding protein γ | > 10 | |
| DP2 | L40386 | E2F dimerization partner DP2 | > 10 | |
| E2F5 | U15642 | E2F transcription factor 5 | > 10 | |
| JUN | U65928 | 1p32 | V-jun avian sarcoma virus oncogene homolog | 8 |
| MYBL2 | X13293 | 20q13.1 | V-myb avian myeloblastosis viral oncogene | |
| MYC | M13929 | 8q24.12 | Avian myelocytomatosis viral oncogene | > 10 |
| PBX2 | X59842 | 6p21.3 | Pre-B-cell transcription factor 2 | > 10 |
| TAF2 | X84003 | TBP associated factor, RNA polymerase 2 | > 10 | |
| TAF2D | X95525 | 10q24 | 100-kd subunit of Pol II | > 10 |
| TBP | X54993 | 6q27 | TATA box binding protein | 6 |
| YES1 | M15990 | 18p11.31 | Yamaguchi sarcoma virual oncogene | > 10 |
| Cell-cycle–related genes | ||||
| CCND1 | X59798 | 11q13 | Cyclin D1 | > 10 |
| CCNG2 | U47414 | 4 | Cyclin G2 | > 10 |
| CDC8 | L16991 | Deoxythymidylate kinase | > 10 | |
| CDK4 | U37022 | 12q14 | Cyclin-dependent kinase 4 | > 10 |
| CKS1 | X54941 | 8q21 | CDC28 protein kinase 1 | > 10 |
| MDM2 | U33203 | 12q14.3 | Homolog of mouse double minute 2 | > 10 |
| RB1 | L49209 | 13q14.1 | Retinoblastoma, exon 4 | > 10 |
| RBBP2 | S66431 | 12p11 | Retinoblastoma-binding protein 2 | > 10 |
| RBBP5 | X85134 | 1q32 | Retinoblastoma-binding protein 5 | > 10 |
| SKP2 | U33761 | 5p13 | S-phase kinase-associated protein 2 | > 10 |
| Growth factors/receptors | ||||
| ICSBP1 | M91196 | Interferon consensus sequence binding protein 1 | > 10 | |
| IFNA16 | M27318 | 9q22 | Interferon alpha 16 | 6 |
| IFNA201 | K01900 | 9q22 | Interferon alpha-201 | > 10 |
| IL-1R1 | M27492 | 2q12 | Interleukin-1 receptor, type 1 | > 10 |
| IL-3 | M20137 | 5q23 | Interleukin-3 | > 10 |
| IL-8 | M28130 | 4q12 | Interleukin-8 | > 10 |
| IL-13 | U31120 | 5q31 | Interleukin-13 | > 10 |
| IL-13RA1 | Y10659 | Chr X | Interleukin-13 receptor, alpha 1 | > 10 |
| IL-18 | D49950 | 11q22.2 | Interleukin-18 | > 10 |
| ILF3 | U10324 | Interleukin enhancer binding factor 3 | > 10 | |
| LIFR | X61615 | 5p13 | Leukemia inhibitory factor receptor | 4 |
| Signal proteins and others | ||||
| BCL2 | U15173 | Oncogene B-cell leukemia 2 | > 10 | |
| BLK | S76617 | 8p23 | B lymphoid tyrosine kinase | 6 |
| FLI1 | M98833 | 11q24.1 | Friend leukemia virus integration 1 | 4 |
| H1F0 | X03473 | 22q13.1 | H1 histone family, member 0 | > 10 |
| H2BFQ | M60571 | 1q21 | H2B histone family, member Q | > 10 |
| NCK1 | X17576 | 3q21 | Melanoma NCK protein | > 10 |
| NRAS | X02751 | 1p13 | Neuroblastoma RAS viral oncogene homolog | > 10 |
| OGR1 | U48405 | 14q31 | Ovarian cancer G protein-coupled receptor 1 | 6 |
| PRKCB1 | X06318 | 16p12 | Protein kinase C, beta 1 | 8 |
| PRKM8 | U35005 | Protein kinase mitogen-activated 8 (JNK1) | > 10 | |
| RAB2 | M28213 | RAS-associated protein 2 | 8 | |
| RAB9 | U44103 | RAS-associated protein 9 | > 10 | |
| REL | X75042 | 2p13 | V-rel avian reticuloendotheliosis viral oncogene | 6 |
| RXRG | U38480 | 1q22 | Retinoic X receptor gamma | > 10 |
| STAF50 | X82200 | Interferon inducible gene | 8 |
These genes were selected because their expression was up-regulated ≥ 3-fold in at least 4 of 5 mantle cell lymphoma samples as compared to the nonmalignant hyperplastic lymph nodes.
Access indicates GenBank accession number.