Junctional amino acid sequence of TCR BV16
| BV16 . | N-D-N . | BJ . | BJ segment . | Frequency . |
|---|---|---|---|---|
| Patient 6 | ||||
| CASS | RYRID | EQFFGPGTRLTVL | 2S1 | 1/4 |
| CASS | Q*QGENNQ | EQHFGDGTRLSIL | 1S5 | 1/4 |
| CASS | RGVGQRN | ELFFGSGTRLSVL | 2S2 | 1/4 |
| CASS | RTSGNF | YEQYFGPGTRLTVT | 2S7 | 1/4 |
| Patient 8 | ||||
| CASS | RYRID | EQFFGPGTRLTVL | 2S1 | 9/10 |
| CASS | RSYMRG | YNEQFFGPGTRLTVL | 2S1 | 1/10 |
| Patient 12 | ||||
| CASS | QVSRA | HYEQYFGPGTRLTVT | 2S7 | 9/19 |
| CASS | QGGKR | GYTFGSGTRLTVV | 1S2 | 4/19 |
| CASS | RGQGARD | TQYFGPGTRLTVL | 2S3 | 2/19 |
| CASS | LRGLS | EAFFGQGTRLTVV | 1S1 | 1/19 |
| CASS | QEAGGLS | EQFFGPGTRLTVL | 2S1 | 1/19 |
| CASS | LGTLDG | ELFFGEGSRLTVL | 2S2 | 1/19 |
| CASS | PGLVP | YEQYFGPGTRLTVT | 2S7 | 1/19 |
| Patient 20 | ||||
| CASS | RTGTTS | EAFFGQGTRLTVV | 1S1 | 9/21 |
| CASS | ATGTTD | TQYFGPGTRLVL | 2S5 | 3/21 |
| CASS | QGVALHG | EQFFGPGTRLTVL | 2S1 | 2/21 |
| CASS | RTWAGTG | ELFFGEGSRLTVL | 2S2 | 2/21 |
| CASS | QDQ | YNEQFFGPGTRLTVL | 2S1 | 1/21 |
| CASS | GQSTF | STDTQYFGPGTRLTVL | 2S3 | 1/21 |
| CASS | RGQGARD | TQYFGPGTRLTVL | 2S5 | 1/21 |
| CASS | QVFPY | TEAFFGQGTRLTVV | 2S7 | 1/21 |
| CASS | QGGTAGR | SGSFGPGTRLTVL | 1/21 | |
| Patient 22 | ||||
| CASS | AIGP | SYNEQFFGPGTRLTVL | 2S1 | 11/22 |
| CASS | WPGQGA | TEAFFGQGTRLTVV | 1S1 | 3/22 |
| CASS | SYNEQFFGPGTRLTVL | 2S1 | 1/22 | |
| CASS | RSG | EQFFGPGTRLTVL | 2S1 | 1/22 |
| CASS | QDNYF | SYNEQFFGPGTRLTVL | 2S1 | 1/22 |
| CASS | QEKGTRPGH | EQFFGPGTRLTV | 2S1 | 1/22 |
| CAS | GSFSPPG | ELFFGEGSRLTVL | 2S2 | 1/22 |
| CASS | QSGTV | QETQYFGPGTRLLVL | 2S5 | 1/22 |
| CASS | PGA | YEQYFGPGTRLTVT | 2S7 | 1/22 |
| CASS | PGRT | YEQYFGPGTRLTVT | 2S7 | 1/22 |
| Patient 23 | ||||
| CASS | AYRDRRL | NEKLFFGSGTQLSVL | 1S4 | 18/26 |
| CASS | RYRDRRL | NEKLFFGSGTQLSVL | 1S4 | 1/26 |
| CASS | QGTG | SNQPQHFGDGTRLSIL | 1S5 | 1/26 |
| CASS | YRPS | SYNSPLHFGNGTRLTVT | 1S6 | 1/26 |
| CASS | HKTEWDN | EQFFGPGTRLTVL | 2S1 | 1/26 |
| CASS | QDWDRGNTD | TQYFGPGTRLTVL | 2S5 | 1/26 |
| CASS | QLDKNI | QYFGAGTRLSVL | 2S7 | 1/26 |
| CASS | SSQG | SYEQYFGPGTRLTVT | 2S7 | 1/26 |
| CASS | I GQA | YEQYFGPGTRLTVT | 2S7 | 1/26 |
| Patient 24 | ||||
| CASS | RIETYP | YEQYFGPGTRLTVT | 2S7 | 8/14 |
| CASS | QALVPGLAGGP | YEQYFGPGTRLTVT | 2S7 | 2/14 |
| CASS | YRTHN | EQFFGPGTRLTVL | 2S1 | 1/14 |
| CASS | QDLGGWT | EAFFGQGTRLTVV | 1S1 | 1/14 |
| CASS | QVNY | GYTFGSGTRLTVV | 1S2 | 1/14 |
| CASR | AGG | ETQYFGPGTRLLVL | 2S5 | 1/14 |
| Patient 25 | ||||
| CASS | QDFPSGSWE | SYNEQFFGPGTRLTVL | 2S1 | 7/19 |
| CASS | QVQGVAN | VLTFGAGSRLTVL | 1S2 | 3/19 |
| CASS | QRMGG | TNEKLFFGSGTQLSVL | 1S4 | 2/19 |
| CASS | QASGR | YNEQFFGPGTRLTVL | 2S1 | 1/19 |
| CASS | QGPSG | TEAFFGQGT RLTVV | 1S1 | 1/19 |
| CASS | QDRFIGLAGGA | YEQYFGPGTRLTVT | 2S7 | 1/19 |
| CASS | PAGGFPG | ELFFGEGSRLTVL | 2S2 | 1/19 |
| CASS | QVFE | TQYFGPGTRLLVL | 2S5 | 1/19 |
| CASS | HSRDRPNY | GYTFGSGTRLTVV | 1S2 | 1/19 |
| CASS | RGQGARDTL | YFGPGTRLTVL | 2S2 | 1/19 |
| Patient 28 | ||||
| CASS | AIGP | SYNEQFFGPGTRLTVL | 2S1 | 14/18 |
| CASS | RYWP | SYNEQFFGPGTRLTVL | 2S1 | 2/18 |
| CASS | QGGGSGAN | VLTFGAGSRLTVL | 1S2 | 1/18 |
| CASS | LSG | SYNEQFFGPGTRLTVL | 2S1 | 1/18 |
| Patient 29 | ||||
| CASS | HRGQG | TEAFFGQGTRLTVV | 1S1 | 9/15 |
| CASS | QDRAY | GYTFGSGTRLTVV | 1S2 | 3/15 |
| CASS | LSGTAN | TEAFFGQGTRLTVV | 1S1 | 1/15 |
| CASS | QARGSY | GYTFGSGTRLTVV | 1S2 | 1/15 |
| CASS | LSG | SYNEQFFGPGTRLTVL | 2S1 | 1/15 |
| BV16 . | N-D-N . | BJ . | BJ segment . | Frequency . |
|---|---|---|---|---|
| Patient 6 | ||||
| CASS | RYRID | EQFFGPGTRLTVL | 2S1 | 1/4 |
| CASS | Q*QGENNQ | EQHFGDGTRLSIL | 1S5 | 1/4 |
| CASS | RGVGQRN | ELFFGSGTRLSVL | 2S2 | 1/4 |
| CASS | RTSGNF | YEQYFGPGTRLTVT | 2S7 | 1/4 |
| Patient 8 | ||||
| CASS | RYRID | EQFFGPGTRLTVL | 2S1 | 9/10 |
| CASS | RSYMRG | YNEQFFGPGTRLTVL | 2S1 | 1/10 |
| Patient 12 | ||||
| CASS | QVSRA | HYEQYFGPGTRLTVT | 2S7 | 9/19 |
| CASS | QGGKR | GYTFGSGTRLTVV | 1S2 | 4/19 |
| CASS | RGQGARD | TQYFGPGTRLTVL | 2S3 | 2/19 |
| CASS | LRGLS | EAFFGQGTRLTVV | 1S1 | 1/19 |
| CASS | QEAGGLS | EQFFGPGTRLTVL | 2S1 | 1/19 |
| CASS | LGTLDG | ELFFGEGSRLTVL | 2S2 | 1/19 |
| CASS | PGLVP | YEQYFGPGTRLTVT | 2S7 | 1/19 |
| Patient 20 | ||||
| CASS | RTGTTS | EAFFGQGTRLTVV | 1S1 | 9/21 |
| CASS | ATGTTD | TQYFGPGTRLVL | 2S5 | 3/21 |
| CASS | QGVALHG | EQFFGPGTRLTVL | 2S1 | 2/21 |
| CASS | RTWAGTG | ELFFGEGSRLTVL | 2S2 | 2/21 |
| CASS | QDQ | YNEQFFGPGTRLTVL | 2S1 | 1/21 |
| CASS | GQSTF | STDTQYFGPGTRLTVL | 2S3 | 1/21 |
| CASS | RGQGARD | TQYFGPGTRLTVL | 2S5 | 1/21 |
| CASS | QVFPY | TEAFFGQGTRLTVV | 2S7 | 1/21 |
| CASS | QGGTAGR | SGSFGPGTRLTVL | 1/21 | |
| Patient 22 | ||||
| CASS | AIGP | SYNEQFFGPGTRLTVL | 2S1 | 11/22 |
| CASS | WPGQGA | TEAFFGQGTRLTVV | 1S1 | 3/22 |
| CASS | SYNEQFFGPGTRLTVL | 2S1 | 1/22 | |
| CASS | RSG | EQFFGPGTRLTVL | 2S1 | 1/22 |
| CASS | QDNYF | SYNEQFFGPGTRLTVL | 2S1 | 1/22 |
| CASS | QEKGTRPGH | EQFFGPGTRLTV | 2S1 | 1/22 |
| CAS | GSFSPPG | ELFFGEGSRLTVL | 2S2 | 1/22 |
| CASS | QSGTV | QETQYFGPGTRLLVL | 2S5 | 1/22 |
| CASS | PGA | YEQYFGPGTRLTVT | 2S7 | 1/22 |
| CASS | PGRT | YEQYFGPGTRLTVT | 2S7 | 1/22 |
| Patient 23 | ||||
| CASS | AYRDRRL | NEKLFFGSGTQLSVL | 1S4 | 18/26 |
| CASS | RYRDRRL | NEKLFFGSGTQLSVL | 1S4 | 1/26 |
| CASS | QGTG | SNQPQHFGDGTRLSIL | 1S5 | 1/26 |
| CASS | YRPS | SYNSPLHFGNGTRLTVT | 1S6 | 1/26 |
| CASS | HKTEWDN | EQFFGPGTRLTVL | 2S1 | 1/26 |
| CASS | QDWDRGNTD | TQYFGPGTRLTVL | 2S5 | 1/26 |
| CASS | QLDKNI | QYFGAGTRLSVL | 2S7 | 1/26 |
| CASS | SSQG | SYEQYFGPGTRLTVT | 2S7 | 1/26 |
| CASS | I GQA | YEQYFGPGTRLTVT | 2S7 | 1/26 |
| Patient 24 | ||||
| CASS | RIETYP | YEQYFGPGTRLTVT | 2S7 | 8/14 |
| CASS | QALVPGLAGGP | YEQYFGPGTRLTVT | 2S7 | 2/14 |
| CASS | YRTHN | EQFFGPGTRLTVL | 2S1 | 1/14 |
| CASS | QDLGGWT | EAFFGQGTRLTVV | 1S1 | 1/14 |
| CASS | QVNY | GYTFGSGTRLTVV | 1S2 | 1/14 |
| CASR | AGG | ETQYFGPGTRLLVL | 2S5 | 1/14 |
| Patient 25 | ||||
| CASS | QDFPSGSWE | SYNEQFFGPGTRLTVL | 2S1 | 7/19 |
| CASS | QVQGVAN | VLTFGAGSRLTVL | 1S2 | 3/19 |
| CASS | QRMGG | TNEKLFFGSGTQLSVL | 1S4 | 2/19 |
| CASS | QASGR | YNEQFFGPGTRLTVL | 2S1 | 1/19 |
| CASS | QGPSG | TEAFFGQGT RLTVV | 1S1 | 1/19 |
| CASS | QDRFIGLAGGA | YEQYFGPGTRLTVT | 2S7 | 1/19 |
| CASS | PAGGFPG | ELFFGEGSRLTVL | 2S2 | 1/19 |
| CASS | QVFE | TQYFGPGTRLLVL | 2S5 | 1/19 |
| CASS | HSRDRPNY | GYTFGSGTRLTVV | 1S2 | 1/19 |
| CASS | RGQGARDTL | YFGPGTRLTVL | 2S2 | 1/19 |
| Patient 28 | ||||
| CASS | AIGP | SYNEQFFGPGTRLTVL | 2S1 | 14/18 |
| CASS | RYWP | SYNEQFFGPGTRLTVL | 2S1 | 2/18 |
| CASS | QGGGSGAN | VLTFGAGSRLTVL | 1S2 | 1/18 |
| CASS | LSG | SYNEQFFGPGTRLTVL | 2S1 | 1/18 |
| Patient 29 | ||||
| CASS | HRGQG | TEAFFGQGTRLTVV | 1S1 | 9/15 |
| CASS | QDRAY | GYTFGSGTRLTVV | 1S2 | 3/15 |
| CASS | LSGTAN | TEAFFGQGTRLTVV | 1S1 | 1/15 |
| CASS | QARGSY | GYTFGSGTRLTVV | 1S2 | 1/15 |
| CASS | LSG | SYNEQFFGPGTRLTVL | 2S1 | 1/15 |
The CDR3 sequences of different patients were confirmed by independent analyses starting from new RNA isolations from each preserved specimen to exclude potential contamination between samples. Identical sequences are italicized and underlined. N-D-N, nucleotide-diversity-nucleotide; BJ, β chain joining region.