Outcome after peripheral blood stem cell transplantation
| Patient study number . | No. of PBSCs given (cells/kg × 106) . | ANC 0.5 × 109/L . | PLT 20 × 109/L . | RBC TX-independent4-150 . | Spleen size . | Current status4-154 . | Toxicities . |
|---|---|---|---|---|---|---|---|
| 01-001 | 100.0 | 10 | 30 | 51 | 7 cm, day 466 | Alive, day 615; progressive disease, day 539 | M, D, F, pretibial pain |
| 01-002 | 6.8 | 15 | 27 | 199 | 6 cm, day 431 not palpable, day 531 | Alive, day 531; WBC 5.2, HCT 26.7, PLT 75 | M, D, V, F |
| 01-003 | 6.7 | 15 | 15 | NR | 15 cm, day 175 | Alive, day 266; RBC TX-dependent on EPO | M, N, V, D, F |
| 01-004 | 7.5 | 21 | 21 | 273 | Not palpable | Died, day 531; fungal infection | M, N, V, D, F |
| 01-005 | 10.7 (1st) 10.6 (2nd, day 28) | 96 | NR | NR | Increase (see text) | Died, day 185; progressive disease | F |
| 01-006 | 9.6 | 14 | 12 | 186 | 3 cm, day 20 | Alive, day 241; WBC 9.8, HCT 30, PLT 133 on EPO | M, N, V, D, F |
| 02-001 | 11.2 | 34 | 23 | 48 | 14 cm, day 1623 | Alive, day 1623; WBC 4.9, HCT 37, PLT 328 | M |
| 02-002 | 10.4 (1st) 5.9 (2nd, day 38) | 17 | 75 | 200 | Absent | Alive, day 1008; progressive disease, day 648 | F, R |
| 02-003 | No tranplantation | ||||||
| 02-004 | No tranplantation | ||||||
| 02-005 | 3.0 | 21 | 15 | 15 | Not palpable | Alive, day 752; progressive disease, day 357 | M |
| 02-006 | 9.2 | 21 | 15 | 9 | Not palpable | Alive, day 407; progressive disease, day 360 | M |
| 02-007 | 4.2 | 19 | 13 | NR | Not palpable | Alive, day 370; RBC TX-dependent | M, F |
| 02-008 | 5.63 (1st) 5.46 (2nd, day 22) | NR | NR | NR | No data | Died, day 31; graft failure | M |
| 02-009 | No tranplantation | ||||||
| 02-010 | 6.3 | 16 | 12 | No RBC given | Resected before transplantation | Alive, day 97; progressive disease, day 245 | M |
| 02-011 | No tranplantation | ||||||
| 02-012 | 7.9 | 22 | 18 | 18 | No significant change | Alive, day 233; WBC 3.4, HCT 27, PLT 141, ascites resolved | M, N, F |
| 02-013 | 4.8 | 17 | 22 | 40 | Absent | Alive, day 218; WBC 6.4, HCT 31, PLT 73 | M, N, F4-151 |
| 02-014 | 8.4 | 25 | 52 | 49 | 17 cm,‡ day 126 | Alive, day 150; WBC 4.8, HCT 39, PLT 82 | M, N, D4-153 |
| 02-015 | No tranplantation | ||||||
| 03-001 | 6.5 (1st) 6.5 (2nd, day 26) | 32 | 59 | NR | 10 cm, day 54 | Died, day 238; progressive disease | F, M, V, D, R |
| 03-002 | 8.9 (1st) 8.1 (2nd, day 106) | 21 | 138 | 133 | Absent | Alive, day 415; WBC 5.8, HCT 31, PLT 160 | M, F, |
| 03-003 | 10.5 | 17 | 13 | 14 | 5 cm, day 104 | Alive, day 390; WBC 4.7, HCT 31, PLT 272 | M, N, V, F |
| 03-004 | 27.6 | 28 | NR | NR | 12 cm, day 31 | Died, day 246; progressive disease | M, N, V, D, R |
| 03-005 | 15.0 | 91 | NR | NR | 7 cm, day 35 | Died, day 223; respiratory failure | M, N, V, D, F,4-155 R |
| 04-001 | No tranplantation |
| Patient study number . | No. of PBSCs given (cells/kg × 106) . | ANC 0.5 × 109/L . | PLT 20 × 109/L . | RBC TX-independent4-150 . | Spleen size . | Current status4-154 . | Toxicities . |
|---|---|---|---|---|---|---|---|
| 01-001 | 100.0 | 10 | 30 | 51 | 7 cm, day 466 | Alive, day 615; progressive disease, day 539 | M, D, F, pretibial pain |
| 01-002 | 6.8 | 15 | 27 | 199 | 6 cm, day 431 not palpable, day 531 | Alive, day 531; WBC 5.2, HCT 26.7, PLT 75 | M, D, V, F |
| 01-003 | 6.7 | 15 | 15 | NR | 15 cm, day 175 | Alive, day 266; RBC TX-dependent on EPO | M, N, V, D, F |
| 01-004 | 7.5 | 21 | 21 | 273 | Not palpable | Died, day 531; fungal infection | M, N, V, D, F |
| 01-005 | 10.7 (1st) 10.6 (2nd, day 28) | 96 | NR | NR | Increase (see text) | Died, day 185; progressive disease | F |
| 01-006 | 9.6 | 14 | 12 | 186 | 3 cm, day 20 | Alive, day 241; WBC 9.8, HCT 30, PLT 133 on EPO | M, N, V, D, F |
| 02-001 | 11.2 | 34 | 23 | 48 | 14 cm, day 1623 | Alive, day 1623; WBC 4.9, HCT 37, PLT 328 | M |
| 02-002 | 10.4 (1st) 5.9 (2nd, day 38) | 17 | 75 | 200 | Absent | Alive, day 1008; progressive disease, day 648 | F, R |
| 02-003 | No tranplantation | ||||||
| 02-004 | No tranplantation | ||||||
| 02-005 | 3.0 | 21 | 15 | 15 | Not palpable | Alive, day 752; progressive disease, day 357 | M |
| 02-006 | 9.2 | 21 | 15 | 9 | Not palpable | Alive, day 407; progressive disease, day 360 | M |
| 02-007 | 4.2 | 19 | 13 | NR | Not palpable | Alive, day 370; RBC TX-dependent | M, F |
| 02-008 | 5.63 (1st) 5.46 (2nd, day 22) | NR | NR | NR | No data | Died, day 31; graft failure | M |
| 02-009 | No tranplantation | ||||||
| 02-010 | 6.3 | 16 | 12 | No RBC given | Resected before transplantation | Alive, day 97; progressive disease, day 245 | M |
| 02-011 | No tranplantation | ||||||
| 02-012 | 7.9 | 22 | 18 | 18 | No significant change | Alive, day 233; WBC 3.4, HCT 27, PLT 141, ascites resolved | M, N, F |
| 02-013 | 4.8 | 17 | 22 | 40 | Absent | Alive, day 218; WBC 6.4, HCT 31, PLT 73 | M, N, F4-151 |
| 02-014 | 8.4 | 25 | 52 | 49 | 17 cm,‡ day 126 | Alive, day 150; WBC 4.8, HCT 39, PLT 82 | M, N, D4-153 |
| 02-015 | No tranplantation | ||||||
| 03-001 | 6.5 (1st) 6.5 (2nd, day 26) | 32 | 59 | NR | 10 cm, day 54 | Died, day 238; progressive disease | F, M, V, D, R |
| 03-002 | 8.9 (1st) 8.1 (2nd, day 106) | 21 | 138 | 133 | Absent | Alive, day 415; WBC 5.8, HCT 31, PLT 160 | M, F, |
| 03-003 | 10.5 | 17 | 13 | 14 | 5 cm, day 104 | Alive, day 390; WBC 4.7, HCT 31, PLT 272 | M, N, V, F |
| 03-004 | 27.6 | 28 | NR | NR | 12 cm, day 31 | Died, day 246; progressive disease | M, N, V, D, R |
| 03-005 | 15.0 | 91 | NR | NR | 7 cm, day 35 | Died, day 223; respiratory failure | M, N, V, D, F,4-155 R |
| 04-001 | No tranplantation |
ANC indicates absolute neutrophil count; M, mucositis; D, diarrhea; F, fever; V, vomiting; NR, not reached; N, nausea; R, rash; for other abbreviations, see Tables 2 and 3.
Number of days after transplantation (see text for definitions).
Infection due to bacteremia.
Spleen size measured as craniocaudal length by ultrasound.
Clostridium dificile colitis.
Infection due to bacteremia and pneumonia.
Units for WBC and PLT, × 109/L; HCT, %.