Methods and results of the peripheral blood stem cell mobilization
| Mobilization procedure . | No. of patients . | Median (range) no. of days of G-CSF . | Median (range) no. of days of apheresis . | Median (range) no. of PBSCs collected (CD34+ cells/kg × 106) . |
|---|---|---|---|---|
| Steady state3-150 | 2 | 0 | 1.5 (1-2) | 16.8 (14.4-19.1) |
| G-CSF3-151 | 17 | 5 (3-9) | 2 (1-5) | 11.0 (5.4-410) |
| Chemotherapy → G-CSF3-152 | 8 | 19 (17-40)3-153 | 3 (0-8)3-155 | 10.0 (0-18.0)3-155 |
| Mobilization procedure . | No. of patients . | Median (range) no. of days of G-CSF . | Median (range) no. of days of apheresis . | Median (range) no. of PBSCs collected (CD34+ cells/kg × 106) . |
|---|---|---|---|---|
| Steady state3-150 | 2 | 0 | 1.5 (1-2) | 16.8 (14.4-19.1) |
| G-CSF3-151 | 17 | 5 (3-9) | 2 (1-5) | 11.0 (5.4-410) |
| Chemotherapy → G-CSF3-152 | 8 | 19 (17-40)3-153 | 3 (0-8)3-155 | 10.0 (0-18.0)3-155 |
PBSC indicates peripheral blood stem cell; G-CSF, granulocyte colony-stimulating factor.
No treatment given prior to apheresis (patients 02-002, 02-004).
Sixteen patients received G-CSF at 16 μg/kg/d. One patient (04-001) received G-CSF at 10 μg/kg/d for 4 days with 3.7 × 106 CD34+ cells per kilogram collected followed by G-CSF at 15 μg/kg/d for 4 days with 4.8 × 106 CD34+ cells per kilogram collected.
See text for details of chemotherapy given to patients 02-006, 02-008, 02-010, 02-012, 02-013, 02-014, 02-015, 03-001. G-CSF was given at 16 μg/kg/d, except patient 03-001, who received 10 μg/kg/d.
Data not available for 1 patient (02-015).
Patient 02-015 had no apheresis or stem cells collected because of residual circulating blasts (11%).