Distribution of dominant organ involvement as a function of germ line gene use
| VL subtype . | Features of clonal disease . | Amyloid organ-system involvement . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Dominant involved organ . | No. involved . | |||||||||
| Germ line donor . | No. patients . | Myeloma criteria met . | Cardiac . | Renal . | PNS . | Hepatic . | Other . | 1-2 . | ≥ 3 . | |
| VλI | 1c | 8 | 6 | 4 | 0 | 2 | 1 | 1 | 1 | 7 |
| DPL5 | 3 | 1 | 1 | 2 | 0 | 0 | 0 | 3 | 0 | |
| 1e | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | |
| 1a | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
| 1b | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
| VλII | 2a2 | 6 | 1 | 3 | 2 | 1 | 0 | 0 | 3 | 3 |
| 2c.118D9 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
| VλIII | 3r | 7 | 1 | 3 | 2 | 1 | 1 | 0 | 5 | 2 |
| 3p | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | |
| VλVI | 6a | 18 | 5 | 2 | 15 | 0 | 0 | 1 | 16 | 2 |
| VKI | LFVK431 | 4 | 2 | 0 | 2 | 0 | 1 | 1 | 3 | 1 |
| O8-O18 | 7 | 4 | 2 | 3 | 0 | 1 | 1 | 5 | 2 | |
| DPK7 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | |
| TOTALS | 60 | 23 | 15 | 31 | 5 | 5 | 4 | 42 | 18 | |
| VL subtype . | Features of clonal disease . | Amyloid organ-system involvement . | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Dominant involved organ . | No. involved . | |||||||||
| Germ line donor . | No. patients . | Myeloma criteria met . | Cardiac . | Renal . | PNS . | Hepatic . | Other . | 1-2 . | ≥ 3 . | |
| VλI | 1c | 8 | 6 | 4 | 0 | 2 | 1 | 1 | 1 | 7 |
| DPL5 | 3 | 1 | 1 | 2 | 0 | 0 | 0 | 3 | 0 | |
| 1e | 2 | 0 | 0 | 2 | 0 | 0 | 0 | 2 | 0 | |
| 1a | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
| 1b | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
| VλII | 2a2 | 6 | 1 | 3 | 2 | 1 | 0 | 0 | 3 | 3 |
| 2c.118D9 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | |
| VλIII | 3r | 7 | 1 | 3 | 2 | 1 | 1 | 0 | 5 | 2 |
| 3p | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | |
| VλVI | 6a | 18 | 5 | 2 | 15 | 0 | 0 | 1 | 16 | 2 |
| VKI | LFVK431 | 4 | 2 | 0 | 2 | 0 | 1 | 1 | 3 | 1 |
| O8-O18 | 7 | 4 | 2 | 3 | 0 | 1 | 1 | 5 | 2 | |
| DPK7 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | |
| TOTALS | 60 | 23 | 15 | 31 | 5 | 5 | 4 | 42 | 18 | |