Table 4. Epstein-Barr... | American Society of Hematology

Table 4.

Epstein-Barr virus-lymphoproliferative disease following T-cell-depleted allo-SCT

Patient no.	Donor type	EBV-LPD diagnosis			Therapy			Outcome
Patient no.	Donor type	Morphology^4-150	Clonality	Plasma EBV DNA (gEq/mL)	SI	Anti-CD20	DLI	Response	Survival, d	COD
1	Sib	III	Mono	1 800	+	−	+	PD	Dead	EBV-LPD
2	MUD	II	Poly	92 000	+	+	+	CR	Dead	GVHD
3	MUD	II	Poly	6 500	+	+	−	CR	Alive, 620+	—
4	Sib	III	Mono	790 000	+	+	+	PD	Dead	EBV-LPD
5	Sib	III	Mono	128 000	+	+	−	CR	Alive, 351+	—
6	Sib	II	Mono	74 000	+	+	−	CR	Dead	GVHD
7	MUD	III	Mono	133 000	+	+	+	PD	Dead	EBV-LPD
8	Sib	ND	Mono	7 900	+	−	−	PD	Dead	EBV-LPD
9	MUD	ND	ND	310 000	−	−	+	CR	Dead	GVHD
10	MUD	III	Mono	206 000	−	−	−	PD	Dead	EBV-LPD

Patient no.	Donor type	EBV-LPD diagnosis			Therapy			Outcome
Patient no.	Donor type	Morphology^4-150	Clonality	Plasma EBV DNA (gEq/mL)	SI	Anti-CD20	DLI	Response	Survival, d	COD
1	Sib	III	Mono	1 800	+	−	+	PD	Dead	EBV-LPD
2	MUD	II	Poly	92 000	+	+	+	CR	Dead	GVHD
3	MUD	II	Poly	6 500	+	+	−	CR	Alive, 620+	—
4	Sib	III	Mono	790 000	+	+	+	PD	Dead	EBV-LPD
5	Sib	III	Mono	128 000	+	+	−	CR	Alive, 351+	—
6	Sib	II	Mono	74 000	+	+	−	CR	Dead	GVHD
7	MUD	III	Mono	133 000	+	+	+	PD	Dead	EBV-LPD
8	Sib	ND	Mono	7 900	+	−	−	PD	Dead	EBV-LPD
9	MUD	ND	ND	310 000	−	−	+	CR	Dead	GVHD
10	MUD	III	Mono	206 000	−	−	−	PD	Dead	EBV-LPD

gEq/mL indicates genome equivalents of EBV DNA/mL; SI, stop immunosuppression; anti-CD20, monoclonal anti-B-cell therapy; DLI, donor lymphocyte infusion; COD, cause of death; Sib, HLA-identical family donor; Mono, monoclonal disease; PD, progressive disease; MUD, matched unrelated donor; Poly, polyclonal disease; CR, complete remission; GVHD, graft-versus-host disease; ND, not determined.

F4-150

I indicates plasma cell hyperplasia; II, polymorphic hyperplasia; III, non-Hodgkin lymphoma (criteria according to Knowles et al44).

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