Donor red blood cell replacement and incidence of thrombosis
| Donor cells . | No.mice . | Recipient genotype . | No. BM cells injected × 106 . | Age3-150 at necropsy . | Donor RBCs at 5 wk, % . | Donor RBCs at 16 wk, % . | Donor cells at necropsy, % . | Mice with cardiac thrombi, %3-151 . |
|---|---|---|---|---|---|---|---|---|
| BM | 10 | sph/sph | 4.8 -6.0 | 30 -42 | 20 -80 | 0 -20 | 0 | 30 |
| 3 | sph/sph | 4.8 -6.0 | 38 -42 | 5 -80 | 30 -65 | 13 -26 | 0 | |
| 4 | +/? | 4.8 -6.0 | 48 -50 | 0 | 0 | 0 | 0 | |
| BM + PB | 8 | sph/sph | 2.1 -11.93-152 | 23 -29 | 0 -50 | 0 -30 | 0 | 87.5 |
| 8 | sph/sph | 2.1 -11.93-152 | 25 -52 | 10 -90 | 30 -100 | 10 -100 | 0 | |
| 10 | +/? | 2.1 -11.93-152 | 50 -52 | 0 | 0 | 0 | 0 | |
| PB | 9 | sph/sph | 3-152 | 17 -41 | 0 | 0 | 0 | 56 |
| Donor cells . | No.mice . | Recipient genotype . | No. BM cells injected × 106 . | Age3-150 at necropsy . | Donor RBCs at 5 wk, % . | Donor RBCs at 16 wk, % . | Donor cells at necropsy, % . | Mice with cardiac thrombi, %3-151 . |
|---|---|---|---|---|---|---|---|---|
| BM | 10 | sph/sph | 4.8 -6.0 | 30 -42 | 20 -80 | 0 -20 | 0 | 30 |
| 3 | sph/sph | 4.8 -6.0 | 38 -42 | 5 -80 | 30 -65 | 13 -26 | 0 | |
| 4 | +/? | 4.8 -6.0 | 48 -50 | 0 | 0 | 0 | 0 | |
| BM + PB | 8 | sph/sph | 2.1 -11.93-152 | 23 -29 | 0 -50 | 0 -30 | 0 | 87.5 |
| 8 | sph/sph | 2.1 -11.93-152 | 25 -52 | 10 -90 | 30 -100 | 10 -100 | 0 | |
| 10 | +/? | 2.1 -11.93-152 | 50 -52 | 0 | 0 | 0 | 0 | |
| PB | 9 | sph/sph | 3-152 | 17 -41 | 0 | 0 | 0 | 56 |
RBC indicate red blood cell; for other abbreviations, see Table 2.
Age in weeks.
The percentage of mice with thromboses needs clarification in a larger cohort of animals. This does not detract from the conclusions that the 11 mice with donor cells present at necropsy do not have thrombi.
Each mouse was injected with approximately 5 × 1013 +a/+a total PB cells.