Table 3.

Survival of wild-type, X-CGD, and X-CGD transplantation chimera mice in Burkholderia cepacia infection

% NBTWT 100%X-CGD 0%Female X-CGD carrier 40%-60%3-150WT/X-CGDMSCV-m91Neo/X-CGD
9%-16%20%-26%32%-41%16%-17%30%-42%
109 0/5        
108 8/8 0/6       
107 9/9 0/6       
106  0/3       
105  0/10 10/10 0/6     
104  0/4       
103 3/3 0/15  2/9 3/53-151 8/93-151 0/2 7/73-151 
102  0/4       
30  0/4       
% NBTWT 100%X-CGD 0%Female X-CGD carrier 40%-60%3-150WT/X-CGDMSCV-m91Neo/X-CGD
9%-16%20%-26%32%-41%16%-17%30%-42%
109 0/5        
108 8/8 0/6       
107 9/9 0/6       
106  0/3       
105  0/10 10/10 0/6     
104  0/4       
103 3/3 0/15  2/9 3/53-151 8/93-151 0/2 7/73-151 
102  0/4       
30  0/4       

X-linked chronic granulomatous disease (X-CGD) mice were transplanted with either mixtures of wild-type (WT) and X-CGD bone marrow (BM) or X-CGD BM transduced with MSCV-m91Neo and mock-transduced X-CGD BM. WT, X-CGD mice, and X-CGD carrier females were also studied, as indicated. Data show number of mice surviving of total challenged by intraperitoneal injection with the indicated number of B cepacia conidia (as quantitated by colony assay).

F3-150

Mean percentage of nitroblue tetrazolium (NBT) for carrier females studied was 44 ± 6 (n = 10).

F3-151

P < .006 for X-CGD vs transplantation chimera X-CGD mice (Fisher exact test).

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