Indicators of engraftment by 5,10-methylenetetrahydrofolate reductase genotype
| Measure of MTX toxicity . | MTHFR CC genotype (wild type) . | MTHFR CT genotype . | MTHFR TT genotype . |
|---|---|---|---|
| Platelet recovery* | |||
| Days to reach 10 000 platelets/μL | 1.0 (ref) | 1.00 (0.70-1.42) | 0.76 (0.49-1.19) |
| Days to reach 20 000 platelets/μL | 1.0 (ref) | 1.02 (0.71-1.45) | 0.66 (0.42-1.05) |
| Granulocyte recovery | |||
| Days to reach 100 granulocytes/μL | 1.0 (ref) | 0.93 (0.68-1.30) | 1.05 (0.68-1.60) |
| Days to reach 500 granulocytes/μL | 1.0 (ref) | 0.88 (0.63-1.23) | 0.93 (0.74-1.16) |
| Measure of MTX toxicity . | MTHFR CC genotype (wild type) . | MTHFR CT genotype . | MTHFR TT genotype . |
|---|---|---|---|
| Platelet recovery* | |||
| Days to reach 10 000 platelets/μL | 1.0 (ref) | 1.00 (0.70-1.42) | 0.76 (0.49-1.19) |
| Days to reach 20 000 platelets/μL | 1.0 (ref) | 1.02 (0.71-1.45) | 0.66 (0.42-1.05) |
| Granulocyte recovery | |||
| Days to reach 100 granulocytes/μL | 1.0 (ref) | 0.93 (0.68-1.30) | 1.05 (0.68-1.60) |
| Days to reach 500 granulocytes/μL | 1.0 (ref) | 0.88 (0.63-1.23) | 0.93 (0.74-1.16) |
Rate ratios of recovery and 95% confidence intervals are presented. A rate ratio <1.0 indicates slower cell count recovery than in the wild-type reference group (CC genotype). MTX indicates methotrexate. See Table 1 for other abbreviation.
Cox regression analyses, adjusted for age (4 groups), sex, conditioning regimen, total MTX dose, weight (kg), height (cm), and mean creatinine levels (days 1-12).