Principal toxic effects of fludarabine phosphate therapy
| Toxic effect . | All patients, % (n = 175) . | Prior therapy, % (n = 62) . | No prior therapy, % (n = 113) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| III . | IV . | V . | III . | IV . | V . | III . | IV . | V . | |
| Neutropenia | 39 | 20 | 0 | 43 | 25 | 0 | 36 | 18 | 0 |
| Thrombocytopenia | 18 | 0 | 0 | 27 | 1 | 0 | 13 | 0 | 0 |
| Anemia | 20 | 7 | 0 | 19 | 13 | 0 | 20 | 4 | 0 |
| Fatigue | 9 | 0 | 0 | 18 | 0 | 0 | 4 | 0 | 0 |
| Infection | 8 | 0 | 4 | 16 | 0 | 6 | 4 | 0 | 3 |
| Lymphopenia | 11 | 0 | 0 | 11 | 0 | 0 | 12 | 0 | 0 |
| Dyspnea | 2 | 2 | 0 | 3 | 5 | 0 | 3 | 0 | 0 |
| Toxic effect . | All patients, % (n = 175) . | Prior therapy, % (n = 62) . | No prior therapy, % (n = 113) . | ||||||
|---|---|---|---|---|---|---|---|---|---|
| III . | IV . | V . | III . | IV . | V . | III . | IV . | V . | |
| Neutropenia | 39 | 20 | 0 | 43 | 25 | 0 | 36 | 18 | 0 |
| Thrombocytopenia | 18 | 0 | 0 | 27 | 1 | 0 | 13 | 0 | 0 |
| Anemia | 20 | 7 | 0 | 19 | 13 | 0 | 20 | 4 | 0 |
| Fatigue | 9 | 0 | 0 | 18 | 0 | 0 | 4 | 0 | 0 |
| Infection | 8 | 0 | 4 | 16 | 0 | 6 | 4 | 0 | 3 |
| Lymphopenia | 11 | 0 | 0 | 11 | 0 | 0 | 12 | 0 | 0 |
| Dyspnea | 2 | 2 | 0 | 3 | 5 | 0 | 3 | 0 | 0 |
Roman numerals indicate common toxicity criteria grade according to the National Cancer Institute system.