Table 2.

Laboratory data at study entry

VariableNInitial registrationFAMP therapy
All patients, % (n = 231)Observation longer than 1 y, % (n = 54)Overall, % (n = 182)No prior therapy, % (n = 118)Prior therapy, % (n = 64)
Hemoglobin level less than 120 g/L 230 69 34* 81 81 81  
Platelet level less than 150 × 109/L 230 21 4* 28 27 29 
IgM at least 40 g/L 226 52 26* 61 65 52  
IgA less than 0.6 g/L 230 42 35 43 37 55† 
IgG less than 7 g/L 230 57 54 58 54 64  
κ Light chain 225 68 66 67 67 68  
LDH greater than ULN 229 9 4 12 13 11  
Albumin level less than 35 g/L 231 32 17* 37 35 41  
β2M at least 3 mg/L 225 50 25* 59 63 52  
Marrow involved at least 50% 129 21 17 23 26 17  
CRP at least 1.0 mg/L 219 51 31* 57 54 63  
ESR at least 100 mm/hour 201 37 30 38 37 39 
Cryoglobulinemia 138 7 9 6 7 6  
Viscosity at least 4 cP 150 16 0* 20 23 15 
VariableNInitial registrationFAMP therapy
All patients, % (n = 231)Observation longer than 1 y, % (n = 54)Overall, % (n = 182)No prior therapy, % (n = 118)Prior therapy, % (n = 64)
Hemoglobin level less than 120 g/L 230 69 34* 81 81 81  
Platelet level less than 150 × 109/L 230 21 4* 28 27 29 
IgM at least 40 g/L 226 52 26* 61 65 52  
IgA less than 0.6 g/L 230 42 35 43 37 55† 
IgG less than 7 g/L 230 57 54 58 54 64  
κ Light chain 225 68 66 67 67 68  
LDH greater than ULN 229 9 4 12 13 11  
Albumin level less than 35 g/L 231 32 17* 37 35 41  
β2M at least 3 mg/L 225 50 25* 59 63 52  
Marrow involved at least 50% 129 21 17 23 26 17  
CRP at least 1.0 mg/L 219 51 31* 57 54 63  
ESR at least 100 mm/hour 201 37 30 38 37 39 
Cryoglobulinemia 138 7 9 6 7 6  
Viscosity at least 4 cP 150 16 0* 20 23 15 

LDL indicates lactate dehydrogenase; ULN, upper limit of normal range; β2M, β2-microglobulin; CRP, C-reactive protein; and ESR, erythrocyte sedimentation rate.

*

P < .05 compared with group registering for treatment step within 1 year of registration for initial step.

†

P < .05 compared with no-prior-therapy group.

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