Table 1.

Patient characteristics at study entry

CharacteristicInitial registrationFAMP therapy
All patients, % (n = 231)Observation longer than 1 y, % (n = 54)Overall, % (n = 182)No prior therapy, % (n = 118)Prior therapy, % (n = 64)
Age at least 70 y 35 43 33 29 41 
Men 59 63 58 58 56  
Performance status greater than 1 4* 13  
Disease duration longer than 1 y 34 25 39 19 76 
Fatigue 56 13* 70 68 75 
Dizziness 16 0* 21 21 21  
Visual disturbance 12 2* 14 13 16 
Bleeding 19 4* 24 27 17 
Infection 
Lymphadenopathy 19 4* 24 30 14 
Hepatomegaly 0* 10 12 
Splenomegaly 17 2* 22 26 14 
CharacteristicInitial registrationFAMP therapy
All patients, % (n = 231)Observation longer than 1 y, % (n = 54)Overall, % (n = 182)No prior therapy, % (n = 118)Prior therapy, % (n = 64)
Age at least 70 y 35 43 33 29 41 
Men 59 63 58 58 56  
Performance status greater than 1 4* 13  
Disease duration longer than 1 y 34 25 39 19 76 
Fatigue 56 13* 70 68 75 
Dizziness 16 0* 21 21 21  
Visual disturbance 12 2* 14 13 16 
Bleeding 19 4* 24 27 17 
Infection 
Lymphadenopathy 19 4* 24 30 14 
Hepatomegaly 0* 10 12 
Splenomegaly 17 2* 22 26 14 

FAMP indicates fludarabine.

*

P < .05 compared with group registering for treatment step within 1 year of registration for initial step.

P < .05 compared with no-prior-therapy group.

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