Effect of high doses of growth factors on apoptosis and proliferation of CD34+kit+ cells (n = 4)
| Factor tested . | Effect on apoptosis5-150 . | Effect on proliferation5-151 . |
|---|---|---|
| (no factor) | No effect | No effect |
| KL | Inhibition | Stimulatory |
| FLT3L | Inhibition | Stimulatory |
| TPO | Inhibition | Stimulatory |
| IGF-1 | Inhibition | No effect |
| VEGF | No effect | No effect |
| FGF-2 | No effect | No effect |
| HGF | No effect | No effect |
| Factor tested . | Effect on apoptosis5-150 . | Effect on proliferation5-151 . |
|---|---|---|
| (no factor) | No effect | No effect |
| KL | Inhibition | Stimulatory |
| FLT3L | Inhibition | Stimulatory |
| TPO | Inhibition | Stimulatory |
| IGF-1 | Inhibition | No effect |
| VEGF | No effect | No effect |
| FGF-2 | No effect | No effect |
| HGF | No effect | No effect |
See footnote to Table 1 for abbreviations.
Percentage of apoptotic cells at day 4: (no factor) (34 ± 13%); KL (7 ± 3%); FLT3 ligand (12 ± 6%); TPO (7 ± 4%); IGF-1 (15 ± 7%); VEGF (37 ± 15%); FGF-2 (32 ± 19%); and HGF (34 ± 10%).
Determined by the presence of cell division and cell cluster formation.