Number of patients and controls, sex- and age-adjusted odd ratios and 95% confidence intervals for combination status of methylenetetrahydrofolate reductase and methionine synthase
| MTHFR 677 and 1298 . | MS2756 . | Patients n = 953-150 . | Controls n = 243 . | OR . | 95% CI . | P value . |
|---|---|---|---|---|---|---|
| CT/TT and AC/CC (Group A) | AA/AG | 61 (63.5%) | 200 (82.3%) | 1.00 | Reference | |
| (Groups B, C) | 34 (34.%) | 43 (17.7%) | 2.51 | 1.45-4.37 | .001 | |
| CT/TT and AC/CC (Group B) | GG | 6 (6.3%) | 6 (2.5%) | 3.86 | 1.16-12.8 | |
| CC and AA (Group C) | AA/AG | 28 (28.6%) | 37 (15.2%) | 2.32 | 1.28-4.18 |
| MTHFR 677 and 1298 . | MS2756 . | Patients n = 953-150 . | Controls n = 243 . | OR . | 95% CI . | P value . |
|---|---|---|---|---|---|---|
| CT/TT and AC/CC (Group A) | AA/AG | 61 (63.5%) | 200 (82.3%) | 1.00 | Reference | |
| (Groups B, C) | 34 (34.%) | 43 (17.7%) | 2.51 | 1.45-4.37 | .001 | |
| CT/TT and AC/CC (Group B) | GG | 6 (6.3%) | 6 (2.5%) | 3.86 | 1.16-12.8 | |
| CC and AA (Group C) | AA/AG | 28 (28.6%) | 37 (15.2%) | 2.32 | 1.28-4.18 |
MTHFR indicates methylenetetrahydrofolate reductase; for other abbreviations, see Table 1.
Patients were genotyped for all three polymorphisms. Three patients were excluded.