Number of patients and controls, sex- and age-adjusted odd ratios and 95% confidence intervals for methylenetetrahydrofolate reductase 677 (MTHFR677) and MTHFR1298
| MTHFR677 . | MTHFR1298 . | Patients n = 97* . | Controls n = 243 . | OR . | 95% CI . | P value . |
|---|---|---|---|---|---|---|
| CC | AA | 29 (29.9%) | 37 (15.2%) | 1.00 | Reference | |
| CT/TT | AC/CC | 68 (70.1%) | 206 (84.8%) | 0.45 | 0.25-0.80 | .007 |
| CC | AC | 14 (14.4%) | 35 (14.4%) | 0.49 | 0.22-1.12 | |
| CC | CC | 1 (1.0%) | 9 (3.7%) | 0.14 | 0.02-1.17 | |
| CT | AA | 20 (20.6%) | 86 (35.4%) | 0.30 | 0.15-0.61 | |
| CT | AC | 19 (19.6%) | 40 (16.5%) | 0.72 | 0.34-1.52 | |
| CT | CC | 0 | 0 | |||
| TT | AA | 13 (13.4%) | 36 (14.8%) | 0.46 | 0.20-1.05 | |
| TT | AC | 1 (1.0%) | 0 | NE | ||
| TT | CC | 0 | 0 |
| MTHFR677 . | MTHFR1298 . | Patients n = 97* . | Controls n = 243 . | OR . | 95% CI . | P value . |
|---|---|---|---|---|---|---|
| CC | AA | 29 (29.9%) | 37 (15.2%) | 1.00 | Reference | |
| CT/TT | AC/CC | 68 (70.1%) | 206 (84.8%) | 0.45 | 0.25-0.80 | .007 |
| CC | AC | 14 (14.4%) | 35 (14.4%) | 0.49 | 0.22-1.12 | |
| CC | CC | 1 (1.0%) | 9 (3.7%) | 0.14 | 0.02-1.17 | |
| CT | AA | 20 (20.6%) | 86 (35.4%) | 0.30 | 0.15-0.61 | |
| CT | AC | 19 (19.6%) | 40 (16.5%) | 0.72 | 0.34-1.52 | |
| CT | CC | 0 | 0 | |||
| TT | AA | 13 (13.4%) | 36 (14.8%) | 0.46 | 0.20-1.05 | |
| TT | AC | 1 (1.0%) | 0 | NE | ||
| TT | CC | 0 | 0 |
NE, not estimated; for other abbreviations, see Table 1.
One patient was excluded because DNA was not amplified by PCR.