Patient and donor characteristics
| . | Filgrastim . | Control . |
|---|---|---|
| No. patients | 21* | 21 |
| Patient median age (y) (range) | 39 (15-52) | 40 (21-51) |
| Patient sex, M/F | 11/10 | 11/10 |
| Diagnosis | ||
| Leukemia/myelodysplasia | 16 | 15 |
| Lymphoma | 2 | 2 |
| Solid tumor | 3 | 4 |
| Disease status | ||
| Early | 6 | 6 |
| Intermediate | 3 | 2 |
| Advanced | 12 | 13 |
| Refractory disease | 10 | 4 |
| Prior transplantation | 2 | 2 |
| Prep regimen | ||
| Total body irradiation–based | 12 | 12 |
| Busulfan-based | 5 | 5 |
| Carmustine-based | 4 | 4 |
| GVHD prophylaxis | ||
| Tacrolimus/steroids | 4 | 5 |
| Tacrolimus/micromethotrexate | 17 | 16 |
| Donor median age (y) (range) | 36 (8-46) | 39 (4-56) |
| Donor sex, M/F | 10/11 | 10/11 |
| Pair sex-mismatched | 9 | 9 |
| Pair cytomegalovirus serology −/− | 6 | 1 |
| Pair ABO | ||
| Matched | 15 | 15 |
| Major mismatch | 2 | 3 |
| Minor mismatch | 4 | 3 |
| Blood stem cell graft | ||
| Median nucleated cells × 108/kg (range) | 5.8 (2.3-19.1) | 8.3† (2.8-23.8) |
| Median CD34+ cells × 106/kg (range) | 4.8 (2.2-20.5) | 4.3 (1.9-16.2) |
| . | Filgrastim . | Control . |
|---|---|---|
| No. patients | 21* | 21 |
| Patient median age (y) (range) | 39 (15-52) | 40 (21-51) |
| Patient sex, M/F | 11/10 | 11/10 |
| Diagnosis | ||
| Leukemia/myelodysplasia | 16 | 15 |
| Lymphoma | 2 | 2 |
| Solid tumor | 3 | 4 |
| Disease status | ||
| Early | 6 | 6 |
| Intermediate | 3 | 2 |
| Advanced | 12 | 13 |
| Refractory disease | 10 | 4 |
| Prior transplantation | 2 | 2 |
| Prep regimen | ||
| Total body irradiation–based | 12 | 12 |
| Busulfan-based | 5 | 5 |
| Carmustine-based | 4 | 4 |
| GVHD prophylaxis | ||
| Tacrolimus/steroids | 4 | 5 |
| Tacrolimus/micromethotrexate | 17 | 16 |
| Donor median age (y) (range) | 36 (8-46) | 39 (4-56) |
| Donor sex, M/F | 10/11 | 10/11 |
| Pair sex-mismatched | 9 | 9 |
| Pair cytomegalovirus serology −/− | 6 | 1 |
| Pair ABO | ||
| Matched | 15 | 15 |
| Major mismatch | 2 | 3 |
| Minor mismatch | 4 | 3 |
| Blood stem cell graft | ||
| Median nucleated cells × 108/kg (range) | 5.8 (2.3-19.1) | 8.3† (2.8-23.8) |
| Median CD34+ cells × 106/kg (range) | 4.8 (2.2-20.5) | 4.3 (1.9-16.2) |