Correlation between IL-7 and lymphocyte parameters in HIV-infected adults and children
| . | HIV-infected children (n = 41) . | HIV-infected adults (n = 51) . | ||||
|---|---|---|---|---|---|---|
| r . | P . | Median (range) . | r . | P . | Median (range) . | |
| CD3 (cells/μL) | −0.69 | < .0001 | 1552 (259-5813) | −0.43 | .002 | 845 (83-2775) |
| CD4 (cells/μL) | −0.77 | < .0001 | 504 (0-2558) | −0.68 | < .0001 | 121 (0-498) |
| CD8 (cells/μL) | −0.54 | .0007 | 1014 (42-4534) | −0.34 | .02 | 633 (72-2450) |
| CD4+CD45RA+(cells/μL) | −0.70 | .0004 | 375 (0-1171) | −0.69 | < .0001 | 47 (2-222)* |
| CD4+CD45RO+(cells/μL) | −0.78 | < .0001 | 188 (0-476) | 0.02 | .91 | 103 (14-307)* |
| CD4:CD8 | −0.57 | .0003 | 0.49 (0-1.88) | −0.60 | < .0001 | 0.16 (0-0.56) |
| B cell (cells/μL) | −0.33 | .04 | 753 (172-2789) | 0.03 | .87 | 372 (21-1029) |
| IL-7 (pg/mL) | 14.1 (2.5-64.0) | 18.0 (4.9-55.0) | ||||
| . | HIV-infected children (n = 41) . | HIV-infected adults (n = 51) . | ||||
|---|---|---|---|---|---|---|
| r . | P . | Median (range) . | r . | P . | Median (range) . | |
| CD3 (cells/μL) | −0.69 | < .0001 | 1552 (259-5813) | −0.43 | .002 | 845 (83-2775) |
| CD4 (cells/μL) | −0.77 | < .0001 | 504 (0-2558) | −0.68 | < .0001 | 121 (0-498) |
| CD8 (cells/μL) | −0.54 | .0007 | 1014 (42-4534) | −0.34 | .02 | 633 (72-2450) |
| CD4+CD45RA+(cells/μL) | −0.70 | .0004 | 375 (0-1171) | −0.69 | < .0001 | 47 (2-222)* |
| CD4+CD45RO+(cells/μL) | −0.78 | < .0001 | 188 (0-476) | 0.02 | .91 | 103 (14-307)* |
| CD4:CD8 | −0.57 | .0003 | 0.49 (0-1.88) | −0.60 | < .0001 | 0.16 (0-0.56) |
| B cell (cells/μL) | −0.33 | .04 | 753 (172-2789) | 0.03 | .87 | 372 (21-1029) |
| IL-7 (pg/mL) | 14.1 (2.5-64.0) | 18.0 (4.9-55.0) | ||||
n = 33. CD4+CD45RA+ cells in the adult HIV-infected group were also CD62L+.