Mylotarg induces apoptosis in HL-60 cells in a dose-dependent manner*
| . | Concentration Mylotarg . | |||||
|---|---|---|---|---|---|---|
| 0 pg/ mL . | 1 pg/ mL . | 10 pg/ mL . | 100 pg/ mL . | 1 μg/ mL . | 10 μg/ mL . | |
| Annexin V+/PI−(%) | ||||||
| At 72 h | 12.8 | 11.4 | 12.8 | 17.1 | 19.0 | 21.6 |
| At 96 h | 7.5 | 10.8 | 13.8 | 17.2 | 17.2 | 21.0 |
| Annexin V+/PI+(%) | ||||||
| At 72 h | 18.9 | 23.1 | 27.5 | 38.4 | 39.8 | 38.7 |
| At 96 h | 20.6 | 22.9 | 31.3 | 44.1 | 51.2 | 50.9 |
| Total annexin V+(%) | ||||||
| At 72 h | 31.7 | 34.5 | 40.3 | 55.5 | 58.8 | 60.3 |
| At 96 h | 28.1 | 33.6 | 45.1 | 61.3 | 68.4 | 71.9 |
| . | Concentration Mylotarg . | |||||
|---|---|---|---|---|---|---|
| 0 pg/ mL . | 1 pg/ mL . | 10 pg/ mL . | 100 pg/ mL . | 1 μg/ mL . | 10 μg/ mL . | |
| Annexin V+/PI−(%) | ||||||
| At 72 h | 12.8 | 11.4 | 12.8 | 17.1 | 19.0 | 21.6 |
| At 96 h | 7.5 | 10.8 | 13.8 | 17.2 | 17.2 | 21.0 |
| Annexin V+/PI+(%) | ||||||
| At 72 h | 18.9 | 23.1 | 27.5 | 38.4 | 39.8 | 38.7 |
| At 96 h | 20.6 | 22.9 | 31.3 | 44.1 | 51.2 | 50.9 |
| Total annexin V+(%) | ||||||
| At 72 h | 31.7 | 34.5 | 40.3 | 55.5 | 58.8 | 60.3 |
| At 96 h | 28.1 | 33.6 | 45.1 | 61.3 | 68.4 | 71.9 |
Data from one representative experiment of 3 are shown.