Total number (×103) of progenitor and precursor cells in the marrow of wild-type and GATA-1lowmice
. | Progenitor cells . | Precursor cells . | ||||
---|---|---|---|---|---|---|
CFU-GM . | BFU-E . | CFU-E . | TER-119+/4A5+ . | TER-119+ . | 4A5+ . | |
Wild-type | 310 | 410 | 280 | 1500 | 82 500 | 1150 |
GATA-1low | 80 | 180 | 250 | 1500 | 27 500 | 1910 |
. | Progenitor cells . | Precursor cells . | ||||
---|---|---|---|---|---|---|
CFU-GM . | BFU-E . | CFU-E . | TER-119+/4A5+ . | TER-119+ . | 4A5+ . | |
Wild-type | 310 | 410 | 280 | 1500 | 82 500 | 1150 |
GATA-1low | 80 | 180 | 250 | 1500 | 27 500 | 1910 |
The values are calculated from those presented in Table 1 and Figure 5 and from the percentages of precursor cells calculated by fluorescence-activated cell sorting and summarized in the text; the calculations take into account that the bone marrow analyzed in our experiments corresponds to 10% of all the marrow of a mouse.27
CFU-GM indicates granulocyte-macrophage colony-forming units; BFU-E, burst-forming units–erythroid; and CFU-E, colony-forming units–erythroid.