Serum free light-chain concentrations in 28 patients with nonsecretory myeloma
| . | . | Free κ: mg/L Mean (range) . | Free λ: mg/L Mean (range) . | κ/λ ratio: Mean (range) . | Bone marrow plasma cells, % . | Other results . |
|---|---|---|---|---|---|---|
| Normal sera | 8.4 (3.6-15.9) | 14.5 (8.1-33) | 0.60 (0.36-1.0) | — | ||
| Nonsecretory myeloma sera | ||||||
| 12: elevated free κ and increased κ/λ ratio | 1 | 1 754 | 1.6 | 1 096 | 85 | IFE κ +/− |
| 2 | 1 201 | 3.6 | 333 | 82 | BJP κ +/− | |
| 3 | 935 | 11 | 85 | 70 | ||
| 4 | 487 | 6.6 | 74 | 20 | ||
| 5 | 931 | 13.2 | 71 | > 90 | IFE κ +/− | |
| 6 | 730 | 11.1 | 65 | 35 | ||
| 7 | 978 | 19.4 | 50 | 65 | ||
| 8 | 920 | 26.3 | 35 | 14* | ||
| 9 | 789 | 25.6 | 31 | > 50 | BJP κ +/− | |
| 10 | 480 | 23.8 | 20 | 30 | ||
| 11 | 151 | 11.5 | 13 | 66 | Hist κ+ve | |
| 12 | 79.8 | 30.8 | 2.6 | 50 | ||
| 7: elevated free λ with reduced κ/λ ratio | 13 | 11.2 | 196 | 0.057 | 20 | IFE λ+ |
| 14 | 2.7 | 50.9 | 0.053 | 74 | ||
| 15 | 2.6 | 61 | 0.043 | 6* | ||
| 16 | 17.8 | 624 | 0.029 | 8 | IFEλ+BJPλ+/− | |
| 17 | 3.8 | 144 | 0.026 | 70 | ||
| 18 | 7.7 | 389 | 0.019 | 60 | ||
| 19 | 2.8 | 481 | 0.005 | 29 | IFE λ+ | |
| 4: suppression of either κ, λ or both flc | 20 | 4.5 | 6 | 0.75 | 21 | |
| 21 | 1.2 | 1.6 | 0.75 | 55 | ||
| 22 | 2.4 | 8.1 | 0.296 | 34 | ||
| 23 | 3.6 | 13.1 | 0.274 | 70 | ||
| 5: κ or λ normal or borderline and normal κ/λ ratio | 24 | 16.2 | 23.4 | 0.692 | 67 | |
| 25 | 20.7 | 33 | 0.627 | 73 | ||
| 26 | 77 | 142 | 0.543 | 18 | IFE λ+ | |
| 27 | 8.3 | 17.4 | 0.477 | 9* | ||
| 28 | 8.6 | 25.2 | 0.341 | 80 |
| . | . | Free κ: mg/L Mean (range) . | Free λ: mg/L Mean (range) . | κ/λ ratio: Mean (range) . | Bone marrow plasma cells, % . | Other results . |
|---|---|---|---|---|---|---|
| Normal sera | 8.4 (3.6-15.9) | 14.5 (8.1-33) | 0.60 (0.36-1.0) | — | ||
| Nonsecretory myeloma sera | ||||||
| 12: elevated free κ and increased κ/λ ratio | 1 | 1 754 | 1.6 | 1 096 | 85 | IFE κ +/− |
| 2 | 1 201 | 3.6 | 333 | 82 | BJP κ +/− | |
| 3 | 935 | 11 | 85 | 70 | ||
| 4 | 487 | 6.6 | 74 | 20 | ||
| 5 | 931 | 13.2 | 71 | > 90 | IFE κ +/− | |
| 6 | 730 | 11.1 | 65 | 35 | ||
| 7 | 978 | 19.4 | 50 | 65 | ||
| 8 | 920 | 26.3 | 35 | 14* | ||
| 9 | 789 | 25.6 | 31 | > 50 | BJP κ +/− | |
| 10 | 480 | 23.8 | 20 | 30 | ||
| 11 | 151 | 11.5 | 13 | 66 | Hist κ+ve | |
| 12 | 79.8 | 30.8 | 2.6 | 50 | ||
| 7: elevated free λ with reduced κ/λ ratio | 13 | 11.2 | 196 | 0.057 | 20 | IFE λ+ |
| 14 | 2.7 | 50.9 | 0.053 | 74 | ||
| 15 | 2.6 | 61 | 0.043 | 6* | ||
| 16 | 17.8 | 624 | 0.029 | 8 | IFEλ+BJPλ+/− | |
| 17 | 3.8 | 144 | 0.026 | 70 | ||
| 18 | 7.7 | 389 | 0.019 | 60 | ||
| 19 | 2.8 | 481 | 0.005 | 29 | IFE λ+ | |
| 4: suppression of either κ, λ or both flc | 20 | 4.5 | 6 | 0.75 | 21 | |
| 21 | 1.2 | 1.6 | 0.75 | 55 | ||
| 22 | 2.4 | 8.1 | 0.296 | 34 | ||
| 23 | 3.6 | 13.1 | 0.274 | 70 | ||
| 5: κ or λ normal or borderline and normal κ/λ ratio | 24 | 16.2 | 23.4 | 0.692 | 67 | |
| 25 | 20.7 | 33 | 0.627 | 73 | ||
| 26 | 77 | 142 | 0.543 | 18 | IFE λ+ | |
| 27 | 8.3 | 17.4 | 0.477 | 9* | ||
| 28 | 8.6 | 25.2 | 0.341 | 80 |
IFE +/− indicates immunofixation electrophoresis weak diffuse band; IFE+, weak narrow band; BJP +/−, low concentration Bence Jones protein in urine; Hist, immunohistochemical confirmation of multiple myeloma.
Trephine biopsy positive for myeloma.