Clinical characteristics of 201 acute myeloid leukemia (excluding M3) patients
| . | Total (N = 201) . | ITD (N = 46) . | D835-Mt (N = 8) . | Wt (N = 147) . |
|---|---|---|---|---|
| Age y | 49 | 56 | 53.5 | 48 |
| (15-85) | (15-77) | (17-70) | (15-85) | |
| WBC count (×109/L) | 24.7 | 54.6* | 25.7 | 20.8 |
| (0.9-632) | (2.1-632) | (5-139.5) | (0.9-33.7) | |
| FAB | ||||
| M0 | 3 | 0 | 0 | 3 |
| M1 | 48 | 14 | 2 | 32 |
| M2 | 83 | 8† | 2 | 73 |
| M4 | 47 | 17 | 2 | 28 |
| M5 | 15 | 5 | 2 | 8 |
| M6 | 4 | 1 | 0 | 3 |
| M7 | 1 | 1 | 0 | 0 |
| Cytogenetics | ||||
| t(8;21) | 28 | 2‡ | 1 | 25 |
| inv16 | 6 | 2 | 0 | 4 |
| t(9;22) | 3 | 0 | 0 | 3 |
| del(5) or del(7) | 11 | 2 | 0 | 9 |
| Others | 41 | 5 | 2 | 34 |
| Normal | 82 | 23 | 4 | 55 |
| ND | 30 | 11 | 1 | 18 |
| Outcome | ||||
| CR | 147 | 32 | 6 | 109 |
| Failure | 51 | 13 | 2 | 36 |
| Unevaluable | 3 | 1 | 0 | 2 |
| . | Total (N = 201) . | ITD (N = 46) . | D835-Mt (N = 8) . | Wt (N = 147) . |
|---|---|---|---|---|
| Age y | 49 | 56 | 53.5 | 48 |
| (15-85) | (15-77) | (17-70) | (15-85) | |
| WBC count (×109/L) | 24.7 | 54.6* | 25.7 | 20.8 |
| (0.9-632) | (2.1-632) | (5-139.5) | (0.9-33.7) | |
| FAB | ||||
| M0 | 3 | 0 | 0 | 3 |
| M1 | 48 | 14 | 2 | 32 |
| M2 | 83 | 8† | 2 | 73 |
| M4 | 47 | 17 | 2 | 28 |
| M5 | 15 | 5 | 2 | 8 |
| M6 | 4 | 1 | 0 | 3 |
| M7 | 1 | 1 | 0 | 0 |
| Cytogenetics | ||||
| t(8;21) | 28 | 2‡ | 1 | 25 |
| inv16 | 6 | 2 | 0 | 4 |
| t(9;22) | 3 | 0 | 0 | 3 |
| del(5) or del(7) | 11 | 2 | 0 | 9 |
| Others | 41 | 5 | 2 | 34 |
| Normal | 82 | 23 | 4 | 55 |
| ND | 30 | 11 | 1 | 18 |
| Outcome | ||||
| CR | 147 | 32 | 6 | 109 |
| Failure | 51 | 13 | 2 | 36 |
| Unevaluable | 3 | 1 | 0 | 2 |
Mean (minimum to maximum) values are indicated for age and WBC count. Number of cases is shown in FAB, cytogenetics, and outcome.
ITD indicates internal tandem duplication; WBC, white blood cell; FAB, French-American-British; ND, not determined; CR, complete remission.
P < .0001.
P = .0025.
P = .047.