Nucleotide and amino acid substitutions identified in the IL-12Rβ1 chain–encoding gene in Japanese persons
| . | 705A > G (Q214R) . | 1158T > C (M365T) . | 1196G > C (G378R) . | 1376C > T (H438Y) . | 1637G > A (A525T) . | 1845G > A (G594E) . |
|---|---|---|---|---|---|---|
| Healthy subjects | 13/13/6 | 20/6/6 | 13/14/5 | 32/0/0 | 31/1/0 | 32/0/0 |
| Patients with tuberculosis | 12/3/4 | 11/4/4 | 11/5/3 | 18/1/0 | 18/1/0 | 18/1/0 |
| Patients with atypical mycobacterium infection | 3/3/0 | 4/2/0 | 2/4/0 | 6/0/0 | 5/1/0 | 6/0/0 |
| . | 705A > G (Q214R) . | 1158T > C (M365T) . | 1196G > C (G378R) . | 1376C > T (H438Y) . | 1637G > A (A525T) . | 1845G > A (G594E) . |
|---|---|---|---|---|---|---|
| Healthy subjects | 13/13/6 | 20/6/6 | 13/14/5 | 32/0/0 | 31/1/0 | 32/0/0 |
| Patients with tuberculosis | 12/3/4 | 11/4/4 | 11/5/3 | 18/1/0 | 18/1/0 | 18/1/0 |
| Patients with atypical mycobacterium infection | 3/3/0 | 4/2/0 | 2/4/0 | 6/0/0 | 5/1/0 | 6/0/0 |
The entire nucleotide sequence of the IL-12Rβ1 chain–encoding gene (1989 bp) was determined, and the reduced amino acid sequence was defined. Only missense substitutions are shown: nucleotide substitutions are on the top lines, and amino acid substitutions are in parentheses. The 3 numbers illustrate wild type (wt) wt-homozygotes/wt-mutant (mt) heterozygotes/mt-mt homozygotes are shown at each amino acid position.