Time-course profile and functional classification of genes expressed by E coli K12–stimulated neutrophils
| . | Up-regulated . | . | |||
|---|---|---|---|---|---|
| Early . | Late . | Down-regulated . | |||
| Transient . | Sustained . | Early . | Late . | ||
| Cytokines | GRN | OSM IL1RN | SCYA4 IL8 SCYA20 | S100A9 | S100A8 |
| SCYA3 IL1B GRO2PBEF | |||||
| Receptors | — | PLAURHS1-2 | CCRL2 ADORA2A | SELL IL8RA | IL8RB |
| TNFRSF1A HM74 CD44 | FPR1 CD97 | FCGR3A | |||
| ITGA5 TNFRSF10B | IFNGR1 | ||||
| LILRA2 | |||||
| PTPRC | |||||
| Membrane trafficking | — | CLIC1ATP5E FLOT1 | ATP6J RAB1ATP2B1 NAF1 RAB7SLC16A3 | ATP2A3 | — |
| SSR2 SLC11A2 NAPA | |||||
| Apoptosis regulators | — | TNFAIP3 GADD34 | PPIF BCL2A1 GSTTLp28 | CFLAR PPIA | PIG7 |
| MCL1 | |||||
| Transcription modulators | FOS ZFP36 ETR101 NFKBIA | HIF1A | HMGIY DDIT3 NFE2L2 NFKB1 NFKBIE GC20 | NFE2CEBPB BTF3 | DSIPI MNDA ZNF220BRF2 |
| EGR1 FOSBIRF1 | |||||
| ZNF148 ATF4 | |||||
| PSCDBP | |||||
| Others | BTG2HLA-E | WBP2 G0S2 | SGK MAP2K3 CPD EHD1 | GCL ARPC1B | EVI2B AMPD2 |
| S100P TPT1 | TNFAIP2 | PLEK CD48 DUSP6 FTH1 | LOC51669 | DIFF48 CLN2 | |
| DYRK1APCOLN3 | PTGS2 | MACS PFN1 RTN4 | TALDO1 | MKNK1 | |
| GCP2 RPN2 MME | HSPA10 | CDKN1A LIMK2 PRG1 | ERV1 MYO1E | KIAA0370 | |
| HLA-C HEM1 | ICAM1NPM1 | SH3BP5 ACTG1 ANPEP | KIAA0446 | ARHGDIB | |
| HSPF1 NUMB | HLA-A SAT | HEF1 HNRPC NS1-BP | IFITM1 VDUP1 | ||
| EIF4A1 | LCP2 MAP3K8 NDUFV2 | ICB-1 NCF4 | |||
| HSPCASUI1 | S100A11 MCP | ||||
| IRAK1 | |||||
| Gene expression pattern | LHL | LHH | LLH | HLL | HHL |
| . | Up-regulated . | . | |||
|---|---|---|---|---|---|
| Early . | Late . | Down-regulated . | |||
| Transient . | Sustained . | Early . | Late . | ||
| Cytokines | GRN | OSM IL1RN | SCYA4 IL8 SCYA20 | S100A9 | S100A8 |
| SCYA3 IL1B GRO2PBEF | |||||
| Receptors | — | PLAURHS1-2 | CCRL2 ADORA2A | SELL IL8RA | IL8RB |
| TNFRSF1A HM74 CD44 | FPR1 CD97 | FCGR3A | |||
| ITGA5 TNFRSF10B | IFNGR1 | ||||
| LILRA2 | |||||
| PTPRC | |||||
| Membrane trafficking | — | CLIC1ATP5E FLOT1 | ATP6J RAB1ATP2B1 NAF1 RAB7SLC16A3 | ATP2A3 | — |
| SSR2 SLC11A2 NAPA | |||||
| Apoptosis regulators | — | TNFAIP3 GADD34 | PPIF BCL2A1 GSTTLp28 | CFLAR PPIA | PIG7 |
| MCL1 | |||||
| Transcription modulators | FOS ZFP36 ETR101 NFKBIA | HIF1A | HMGIY DDIT3 NFE2L2 NFKB1 NFKBIE GC20 | NFE2CEBPB BTF3 | DSIPI MNDA ZNF220BRF2 |
| EGR1 FOSBIRF1 | |||||
| ZNF148 ATF4 | |||||
| PSCDBP | |||||
| Others | BTG2HLA-E | WBP2 G0S2 | SGK MAP2K3 CPD EHD1 | GCL ARPC1B | EVI2B AMPD2 |
| S100P TPT1 | TNFAIP2 | PLEK CD48 DUSP6 FTH1 | LOC51669 | DIFF48 CLN2 | |
| DYRK1APCOLN3 | PTGS2 | MACS PFN1 RTN4 | TALDO1 | MKNK1 | |
| GCP2 RPN2 MME | HSPA10 | CDKN1A LIMK2 PRG1 | ERV1 MYO1E | KIAA0370 | |
| HLA-C HEM1 | ICAM1NPM1 | SH3BP5 ACTG1 ANPEP | KIAA0446 | ARHGDIB | |
| HSPF1 NUMB | HLA-A SAT | HEF1 HNRPC NS1-BP | IFITM1 VDUP1 | ||
| EIF4A1 | LCP2 MAP3K8 NDUFV2 | ICB-1 NCF4 | |||
| HSPCASUI1 | S100A11 MCP | ||||
| IRAK1 | |||||
| Gene expression pattern | LHL | LHH | LLH | HLL | HHL |
For abbreviations, see Table 4 and Appendix A1.