Genes expressed by neutrophils differently regulated by KIM5 (pCD1+) and KIM6 (pCD1−) strains ofY pestis
| KIM5-responsive | KIM6-responsive | ||||
| E coliK12 | NC | NC | NC (slightly up-regulated) | Up-regulated | Down-regulated |
| KIM5 | Up-regulated | Down-regulated | NC (slightly up-regulated) | NC (slightly up-regulated) | NC |
| KIM6 | NC | NC | Up-regulated | Up-regulated | Down-regulated |
| Cytokines | GRO1 | — | — | IL1B SCYA3 GRO2 IL1A | LTB S100A9 S100A8 |
| IL8 OSM SCYA4 IL1RN | |||||
| PBEF SCYA20 | |||||
| Receptors | IFNGR2 | — | — | HM74 PLAUR OLR1 CD44 | IFNGR1 LILRA2 EDG6 |
| IL8RB FPR1 CD97 GPR44 | |||||
| Transcription modulators | CROC4 | — | — | COPEBHDAC3 NFKB1 TRIP8 | XIP BRF2 DSIPI ZNF220 BTF3 TOM1 |
| Apoptosis regulators | CFLAR | — | — | PPIFGADD34 IER3 | PIG7 |
| BCL2A1MCL1 | |||||
| Proteases | PPGB | — | — | PSMC4 | CLN2 GCL |
| Protein kinases | CAMKK2 | — | — | — | MKNK1CLK1 RPS6KA1 |
| MAP3K8 | |||||
| Other signal transducers | TPD52L2 | — | — | — | ARHGDIBHCLS1 S100A11 ICB-1 |
| Membrane trafficking | ATP6L | — | — | ATP2B1 RAB1 AQP9 | RAC1 LOC51312 VPS35 |
| RAB5A FLOT1 SLC7A5 | ATP6F SECTM1 | ||||
| Oxidases | — | — | — | PTGS2 | NCF2NCF1 NCF4 |
| Others | BRI3 HLA-C | ADAM8 | FTL | G0S2PLEK FTH1 ACTB | DIFF48 H3F3A MYO1E |
| B2MFACL1 | DAF NPM1 SATHLA-A | TMSB4X VDUP1 ARPC1B | |||
| GCSH TPM3 | PRG1 NS1-BP SOD2 | EVI2B TALDO1 WBSCR1 | |||
| EIF4A1 HNRPC KIAA0415 | MCP | ||||
| NBS1 UBE2B SUI1 | |||||
| Gene expression pattern | LLHL | HHLH | LLLH | LHLH | HLHL |
| KIM5-responsive | KIM6-responsive | ||||
| E coliK12 | NC | NC | NC (slightly up-regulated) | Up-regulated | Down-regulated |
| KIM5 | Up-regulated | Down-regulated | NC (slightly up-regulated) | NC (slightly up-regulated) | NC |
| KIM6 | NC | NC | Up-regulated | Up-regulated | Down-regulated |
| Cytokines | GRO1 | — | — | IL1B SCYA3 GRO2 IL1A | LTB S100A9 S100A8 |
| IL8 OSM SCYA4 IL1RN | |||||
| PBEF SCYA20 | |||||
| Receptors | IFNGR2 | — | — | HM74 PLAUR OLR1 CD44 | IFNGR1 LILRA2 EDG6 |
| IL8RB FPR1 CD97 GPR44 | |||||
| Transcription modulators | CROC4 | — | — | COPEBHDAC3 NFKB1 TRIP8 | XIP BRF2 DSIPI ZNF220 BTF3 TOM1 |
| Apoptosis regulators | CFLAR | — | — | PPIFGADD34 IER3 | PIG7 |
| BCL2A1MCL1 | |||||
| Proteases | PPGB | — | — | PSMC4 | CLN2 GCL |
| Protein kinases | CAMKK2 | — | — | — | MKNK1CLK1 RPS6KA1 |
| MAP3K8 | |||||
| Other signal transducers | TPD52L2 | — | — | — | ARHGDIBHCLS1 S100A11 ICB-1 |
| Membrane trafficking | ATP6L | — | — | ATP2B1 RAB1 AQP9 | RAC1 LOC51312 VPS35 |
| RAB5A FLOT1 SLC7A5 | ATP6F SECTM1 | ||||
| Oxidases | — | — | — | PTGS2 | NCF2NCF1 NCF4 |
| Others | BRI3 HLA-C | ADAM8 | FTL | G0S2PLEK FTH1 ACTB | DIFF48 H3F3A MYO1E |
| B2MFACL1 | DAF NPM1 SATHLA-A | TMSB4X VDUP1 ARPC1B | |||
| GCSH TPM3 | PRG1 NS1-BP SOD2 | EVI2B TALDO1 WBSCR1 | |||
| EIF4A1 HNRPC KIAA0415 | MCP | ||||
| NBS1 UBE2B SUI1 | |||||
| Gene expression pattern | LLHL | HHLH | LLLH | LHLH | HLHL |
Genes were sorted by their expression patterns as follows: first, by the difference between minimum and maximum band intensities; then by their maximum band intensity; and lastly by the alphabetical order of gene symbols. Genes in boldface showed a minimum difference between H and L of more than 5-fold (ie, 3-step increase/decrease in 8 as maximum) in band intensity. Others were detected with the difference of 3- to 5-fold.
NC indicates no change. Abbreviations of gene names were taken from the gene symbols in the Locuslink database of NCBI, where applicable, and are listed in Appendix A1.