Table 1. Treatment of SAD mice with... | American Society of Hematology

Table 1.

Treatment of SAD mice with varied doses of NS3623: effects on hematocrit, MCHC, intracellular cation concentrations, and Gardós channel activity

Dosing groups (mg/kg)	Hematocrit (%)			MCHC (g/dL)			Na⁺ (mmol/kg Hb)			K⁺ (mmol/kg Hb)			Gardós channel (mmol/L cell/min)
Dosing groups (mg/kg)	10	35	100	10	35	100	10	35	100	10	35	100	10	35	100
No. mice	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6
Pretreatment	44.2 ± 2.2	42.9 ± 3.8	44.3 ± 1.3	31.6 ± 1.3	34.3 ± 2.8	33.0 ± 1.0	36.4 ± 5.6	41.6 ± 3.0	35.7 ± 5.6	374.0 ± 11.1	382.7 ± 11.9	404.0 ± 66	12.8 ± 1.1	12.2 ± 1.9	10.0 ± 1.5
11-day treatment	47.0 ± 1.0^†	46.3 ± 5.1	44.9 ± 2.8	29.3 ± 1.9^*	29.2 ± 4.4^‡	32.3 ± 2.6	44.8 ± 7.2^*	49.0 ± 4.2^‡	66.6 ± 18.8^‡	399.6 ± 8.2^‡	418.9 ± 12.0^‡	438.0 ± 46	12.4 ± 2.6	10.1 ± 2.2^‡	9.2 ± 1.1
21-day treatment	49.2 ± 1.3^‡	47.1 ± 2.6^†	51.3 ± 3.8^‡	29.0 ± 1.4^†	28.1 ± 2.6^‡	29.9 ± 1.7^‡	45.8 ± 4.2^†	54.4 ± 7.7^‡	54.9 ± 8.8^‡	402.4 ± 7.5^‡	418.8 ± 12.0^‡	451.0 ± 35	13.5 ± 0.9	9.1 ± 2.7^‡	4.5 ± 1.5^‡

Dosing groups (mg/kg)	Hematocrit (%)			MCHC (g/dL)			Na⁺ (mmol/kg Hb)			K⁺ (mmol/kg Hb)			Gardós channel (mmol/L cell/min)
Dosing groups (mg/kg)	10	35	100	10	35	100	10	35	100	10	35	100	10	35	100
No. mice	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6	n = 5	n = 7	n = 6
Pretreatment	44.2 ± 2.2	42.9 ± 3.8	44.3 ± 1.3	31.6 ± 1.3	34.3 ± 2.8	33.0 ± 1.0	36.4 ± 5.6	41.6 ± 3.0	35.7 ± 5.6	374.0 ± 11.1	382.7 ± 11.9	404.0 ± 66	12.8 ± 1.1	12.2 ± 1.9	10.0 ± 1.5
11-day treatment	47.0 ± 1.0^†	46.3 ± 5.1	44.9 ± 2.8	29.3 ± 1.9^*	29.2 ± 4.4^‡	32.3 ± 2.6	44.8 ± 7.2^*	49.0 ± 4.2^‡	66.6 ± 18.8^‡	399.6 ± 8.2^‡	418.9 ± 12.0^‡	438.0 ± 46	12.4 ± 2.6	10.1 ± 2.2^‡	9.2 ± 1.1
21-day treatment	49.2 ± 1.3^‡	47.1 ± 2.6^†	51.3 ± 3.8^‡	29.0 ± 1.4^†	28.1 ± 2.6^‡	29.9 ± 1.7^‡	45.8 ± 4.2^†	54.4 ± 7.7^‡	54.9 ± 8.8^‡	402.4 ± 7.5^‡	418.8 ± 12.0^‡	451.0 ± 35	13.5 ± 0.9	9.1 ± 2.7^‡	4.5 ± 1.5^‡

Numbers are means ± SD.

.10 > P > .05;

.05 > P> .01;

.01 > P.