Table 5. Comparison of 4 consecutive... | American Society of Hematology

Table 5.

Comparison of 4 consecutive DFCI Consortium Protocols (1981-1995)

	Protocols
	81-01	85-01	87-01	91-01
Years conducted	1981-1985	1985-1987	1987-1991	1991-1995
Patients, no.	289	220	369	377
HR, %	62	63	62	64
Treatment differences
Induction
Methotrexate	high vs low	low	high vs low	high
Asparaginase	none	1 dose	1 dose	none
Weeks of therapy during intensification	20	20	20	30
CNS therapy
SR, cGy	1800	1800	no XRT	no XRT (female), 1800 (male)
HR, cGy	2800	2400	1800	1800
Post-remission steroid	prednisone	prednisone	prednisone	dexamethasone
Remission death rate, %	3.5	3.6	2.0	3.2
5-y ± SE, %
EFS	74 ± 3	78 ± 3	78 ± 2	83 ± 2^5-150
LFS	79 ± 3	82 ± 3	80 ± 2	87 ± 2^5-151

	Protocols
	81-01	85-01	87-01	91-01
Years conducted	1981-1985	1985-1987	1987-1991	1991-1995
Patients, no.	289	220	369	377
HR, %	62	63	62	64
Treatment differences
Induction
Methotrexate	high vs low	low	high vs low	high
Asparaginase	none	1 dose	1 dose	none
Weeks of therapy during intensification	20	20	20	30
CNS therapy
SR, cGy	1800	1800	no XRT	no XRT (female), 1800 (male)
HR, cGy	2800	2400	1800	1800
Post-remission steroid	prednisone	prednisone	prednisone	dexamethasone
Remission death rate, %	3.5	3.6	2.0	3.2
5-y ± SE, %
EFS	74 ± 3	78 ± 3	78 ± 2	83 ± 2^5-150
LFS	79 ± 3	82 ± 3	80 ± 2	87 ± 2^5-151

Comparison of Protocol 91-01 with prior protocols:

EFS P = .03

LFS P = .02

See Table 1 and Table 2 for abbreviations.