Hematologic staging system for patients with erythrodermic cutaneous T-cell lymphoma, as defined by T-cell receptor gene rearrangement studies, Sézary count, and CD4:CD8 ratio
| Hematological stage . | SSCP/PCR TCR gene analysis studies . | Southern blot TCR gene analysis studies . | Number of Sézary cells, % . | Absolute Sézary count, ×109 cells per L . |
|---|---|---|---|---|
| H0 | Polyclonal | Polyclonal | 0 | 0 |
| H1 | Clonal | Polyclonal | < 5 | 0 |
| H2 | Clonal | Clonal | > 5 | < 1 |
| H3 | Clonal | Clonal | > 5 | 1-10 |
| H4 | Clonal | Clonal | > 5 | > 10 |
| Hematological stage . | SSCP/PCR TCR gene analysis studies . | Southern blot TCR gene analysis studies . | Number of Sézary cells, % . | Absolute Sézary count, ×109 cells per L . |
|---|---|---|---|---|
| H0 | Polyclonal | Polyclonal | 0 | 0 |
| H1 | Clonal | Polyclonal | < 5 | 0 |
| H2 | Clonal | Clonal | > 5 | < 1 |
| H3 | Clonal | Clonal | > 5 | 1-10 |
| H4 | Clonal | Clonal | > 5 | > 10 |
SSCP indicates single-strand conformational polymorphism; PCR, polymerase chain reaction; TCR, T-cell receptor.