Presenting features and sensitivity to BAY 36-1677 among cases of acute lymphoblastic leukemia
| Patient . | Age (y) . | Sex . | Leukocyte count (109/L) . | Karyotype . | Phenotype . | Cell survival on stroma (%)* . | Inhibition of cell recovery with BAY 36-1677 (%)† . |
|---|---|---|---|---|---|---|---|
| 11-153 | 17 | M | 1.5 | t(9;22) | Pre-B | 60 | 57 |
| 21-153 | 15 | F | 531.0 | 11q23 | Pre-B | 231 | 31 |
| 31-153 | 11 | M | 70.7 | t(9;22) | Early pre-B | 115 | 88 |
| 4 | 0.2 | F | 138.9 | 11q23 | Early pre-B | 93 | < 1 |
| 5 | 12 | F | 165.5 | t(9;22) | Early pre-B | 161 | 95 |
| 6 | 15 | M | 455.0 | 11q23 | Pre-B | 151 | 85 |
| 7 | 2 | F | 117.0 | t(9;22) | Pre-B | 102 | 69 |
| 8 | 6 | M | 7.3 | t(9;22) | Pre-B | 132 | 95 |
| 9 | 18 | M | 78.6 | t(9;22) | Early pre-B | 86 | < 1 |
| 10 | 5 | M | 4.1 | 53 chrom | Early pre-B | 71 | 94 |
| 11 | 13 | F | 20.7 | t(9;22) | Early pre-B | 67 | 87 |
| 12 | 2 | F | 28.0 | 48 chrom | Early pre-B | 62 | 85 |
| 13 | 6 | M | 72.7 | t(9;22) | Early pre-B | 76 | 78 |
| 14 | 18 | M | 367.0 | t(9;22) | Early pre-B | 57 | 35 |
| 15 | 4 | M | 83.5 | t(9;22) | Early pre-B | 147 | 90 |
| 16 | 8 | M | 497.0 | t(9;22) | Early pre-B | 80 | 17 |
| Patient . | Age (y) . | Sex . | Leukocyte count (109/L) . | Karyotype . | Phenotype . | Cell survival on stroma (%)* . | Inhibition of cell recovery with BAY 36-1677 (%)† . |
|---|---|---|---|---|---|---|---|
| 11-153 | 17 | M | 1.5 | t(9;22) | Pre-B | 60 | 57 |
| 21-153 | 15 | F | 531.0 | 11q23 | Pre-B | 231 | 31 |
| 31-153 | 11 | M | 70.7 | t(9;22) | Early pre-B | 115 | 88 |
| 4 | 0.2 | F | 138.9 | 11q23 | Early pre-B | 93 | < 1 |
| 5 | 12 | F | 165.5 | t(9;22) | Early pre-B | 161 | 95 |
| 6 | 15 | M | 455.0 | 11q23 | Pre-B | 151 | 85 |
| 7 | 2 | F | 117.0 | t(9;22) | Pre-B | 102 | 69 |
| 8 | 6 | M | 7.3 | t(9;22) | Pre-B | 132 | 95 |
| 9 | 18 | M | 78.6 | t(9;22) | Early pre-B | 86 | < 1 |
| 10 | 5 | M | 4.1 | 53 chrom | Early pre-B | 71 | 94 |
| 11 | 13 | F | 20.7 | t(9;22) | Early pre-B | 67 | 87 |
| 12 | 2 | F | 28.0 | 48 chrom | Early pre-B | 62 | 85 |
| 13 | 6 | M | 72.7 | t(9;22) | Early pre-B | 76 | 78 |
| 14 | 18 | M | 367.0 | t(9;22) | Early pre-B | 57 | 35 |
| 15 | 4 | M | 83.5 | t(9;22) | Early pre-B | 147 | 90 |
| 16 | 8 | M | 497.0 | t(9;22) | Early pre-B | 80 | 17 |
Chrom indicates chromosome.
Percentage leukemic cell recovery after 7 days of culture on bone marrow–derived stroma, compared to the number of cells originally seeded.
Percentage inhibition of cell recovery in cultures containing BAY 36-1677 (25 ng/mL), compared to control cultures without the cytokine.
Studies at first (patients 1 and 2) and second (patient 3) relapse.