Summary of major phenotypes affecting immune cell compartments exhibited by mice with targeted disruption of IL-15, IL-15R components, IL-15R downstream signals, and transcription factors affecting IL-15 expression
| Mutation . | Major phenotypes . | References . |
|---|---|---|
| IL-15−/− | NK cells absent | 8 |
| NK-T cell deficiency (thymic and peripheral) | ||
| Memory CD8+ T-cell deficiency | ||
| i-IEL TCRγδ decreased | ||
| i-IEL CD8α α decreased | ||
| Decreased weight, cellularity of peripheral LN | ||
| IRF-1−/− (lacks inducible IL-15) | NK cells deficient, NK cell activity absent | 63, 64 |
| NK-T cell deficiency | ||
| i-IEL CD8α α deficient | ||
| IL-15Rα−/− | NK cells absent | 9 |
| NK-T cell deficiency (30% of wt) | ||
| Single-positive CD8+ T-cell deficiency (thymus) | ||
| CD8+ T-cell deficiency (periphery) | ||
| Memory CD8+ T-cell deficiency | ||
| TCRγδ i-IEL decreased 5- to 10-fold | ||
| IL-2/15Rβ−/− | NK cells absent | 56, 103, 179 |
| i-IELs (TCRα β, CD8α α, TCRγδ) reduced | ||
| NK-T cells deficient | ||
| DETCs absent | ||
| IL-2/15Rβ−/−→tgΔHIL-2/15Rβ | NK cells deficient | 118 |
| i-IEL TCRγδ deficient | ||
| IL-2/15Rβ−/−→tgΔAIL-2/15Rβ | NK cells normal | |
| i-IEL TCRγδ normal | ||
| Decreased induced NK cytotoxicity | ||
| γc−/− | NK cells deficient (greater than 350-fold reduction) | 101,119 |
| T and B cells deficient (10-fold reduction) | ||
| Jak3−/− (γc signal) | NK cells deficient | 120, 121 |
| DETCs absent | ||
| i-IEL TCRγδ deficient | ||
| STAT5a/b−/− (γcsignal) | NK cells deficient | 122 |
| STAT5b−/− (γc signal) | NK cell proliferation defect | 123 |
| NK cell cytotoxicity defect |
| Mutation . | Major phenotypes . | References . |
|---|---|---|
| IL-15−/− | NK cells absent | 8 |
| NK-T cell deficiency (thymic and peripheral) | ||
| Memory CD8+ T-cell deficiency | ||
| i-IEL TCRγδ decreased | ||
| i-IEL CD8α α decreased | ||
| Decreased weight, cellularity of peripheral LN | ||
| IRF-1−/− (lacks inducible IL-15) | NK cells deficient, NK cell activity absent | 63, 64 |
| NK-T cell deficiency | ||
| i-IEL CD8α α deficient | ||
| IL-15Rα−/− | NK cells absent | 9 |
| NK-T cell deficiency (30% of wt) | ||
| Single-positive CD8+ T-cell deficiency (thymus) | ||
| CD8+ T-cell deficiency (periphery) | ||
| Memory CD8+ T-cell deficiency | ||
| TCRγδ i-IEL decreased 5- to 10-fold | ||
| IL-2/15Rβ−/− | NK cells absent | 56, 103, 179 |
| i-IELs (TCRα β, CD8α α, TCRγδ) reduced | ||
| NK-T cells deficient | ||
| DETCs absent | ||
| IL-2/15Rβ−/−→tgΔHIL-2/15Rβ | NK cells deficient | 118 |
| i-IEL TCRγδ deficient | ||
| IL-2/15Rβ−/−→tgΔAIL-2/15Rβ | NK cells normal | |
| i-IEL TCRγδ normal | ||
| Decreased induced NK cytotoxicity | ||
| γc−/− | NK cells deficient (greater than 350-fold reduction) | 101,119 |
| T and B cells deficient (10-fold reduction) | ||
| Jak3−/− (γc signal) | NK cells deficient | 120, 121 |
| DETCs absent | ||
| i-IEL TCRγδ deficient | ||
| STAT5a/b−/− (γcsignal) | NK cells deficient | 122 |
| STAT5b−/− (γc signal) | NK cell proliferation defect | 123 |
| NK cell cytotoxicity defect |
tgΔH indicates transgenic for IL-2/15Rβ with deletion of the cytoplasmic H region; tgΔA, transgenic for IL-2/15Rβ with deletion of the cytoplasmic A region; and LN, lymph node.