Significance of differences between mean megakaryocytic colony numbers at various concentrations of cytokine among healthy and ET progenitor cell cultures
| PEG-rHu MGDF concentration (ng/mL) . | Comparison of nos. of megakaryocytic colonies at given PEG-rHu MGDF concentration* . | ||||
|---|---|---|---|---|---|
| Healthy . | n . | ET . | |||
| P . | signif . | P . | signif . | ||
| 0 vs 0.16 | .8 | ns | 20 | < .001 | vhs |
| 0 vs 0.8 | .2 | ns | 20 | < .001 | vhs |
| 0 vs 4.0 | .1-.05 | ns | 20 | < .001 | vhs |
| 0 vs 20.0 | .01-.001 | hs | 20 | < .001 | vhs |
| 0 vs 50.0 | .001 | hs | 17 | < .001 | vhs |
| 0 vs 100 | < .001 | vhs | 20 | < .001 | vhs |
| 0 vs 200 | < .001 | vhs | 15 | < .001 | vhs |
| 0.16 vs 0.8 | .3 | ns | 20 | .05 | s |
| 0.16 vs 4.0 | .2-.1 | ns | 20 | ∼ .001 | hs |
| 0.16 vs 20.0 | .02-.01 | s | 20 | ∼ .001 | hs |
| 0.16 vs 50.0 | .01-.001 | hs | 17 | ∼ .001 | hs |
| 0.16 vs 100 | < .001 | vhs | 20 | ∼ .001 | hs |
| 0.16 vs 200 | < .001 | vhs | 15 | < .001 | vhs |
| 0.8 vs 4.0 | .6 | ns | 20 | ∼ .1 | ns |
| 0.8 vs 20.0 | ∼ .1 | ns | 20 | ∼ .1 | ns |
| 0.8 vs 50.0 | .05-.02 | s | 17 | .1-.05 | ns |
| 0.8 vs 100 | < .001 | vhs | 20 | ∼ .01 | s |
| 0.8 vs 200 | < .001 | vhs | 16 | < .01 | hs |
| 4.0 vs 20.0 | .3-.2 | ns | 20 | ≧ .9 | ns |
| 4.0 vs 50.0 | .1-.05 | ns | 17 | .6 | ns |
| 4.0 vs 100 | < .001 | vhs | 20 | .3-.2 | ns |
| 4.0 vs 200 | < .001 | vhs | 15 | .01-.001 | hs |
| 20.0 vs 50.0 | ∼ .7 | ns | 17 | .6 | ns |
| 20.0 vs 100 | < .001 | vhs | 20 | .3 | ns |
| 20.0 vs 200 | < .001 | vhs | 15 | .01-.001 | hs |
| 50.0 vs 100 | < .001 | vhs | 17 | .7 | ns |
| 50.0 vs 200 | < .001 | vhs | 15 | .1 | ns |
| 100 vs 200 | .05-.02 | s | 15 | .05 | s |
| PEG-rHu MGDF concentration (ng/mL) . | Comparison of nos. of megakaryocytic colonies at given PEG-rHu MGDF concentration* . | ||||
|---|---|---|---|---|---|
| Healthy . | n . | ET . | |||
| P . | signif . | P . | signif . | ||
| 0 vs 0.16 | .8 | ns | 20 | < .001 | vhs |
| 0 vs 0.8 | .2 | ns | 20 | < .001 | vhs |
| 0 vs 4.0 | .1-.05 | ns | 20 | < .001 | vhs |
| 0 vs 20.0 | .01-.001 | hs | 20 | < .001 | vhs |
| 0 vs 50.0 | .001 | hs | 17 | < .001 | vhs |
| 0 vs 100 | < .001 | vhs | 20 | < .001 | vhs |
| 0 vs 200 | < .001 | vhs | 15 | < .001 | vhs |
| 0.16 vs 0.8 | .3 | ns | 20 | .05 | s |
| 0.16 vs 4.0 | .2-.1 | ns | 20 | ∼ .001 | hs |
| 0.16 vs 20.0 | .02-.01 | s | 20 | ∼ .001 | hs |
| 0.16 vs 50.0 | .01-.001 | hs | 17 | ∼ .001 | hs |
| 0.16 vs 100 | < .001 | vhs | 20 | ∼ .001 | hs |
| 0.16 vs 200 | < .001 | vhs | 15 | < .001 | vhs |
| 0.8 vs 4.0 | .6 | ns | 20 | ∼ .1 | ns |
| 0.8 vs 20.0 | ∼ .1 | ns | 20 | ∼ .1 | ns |
| 0.8 vs 50.0 | .05-.02 | s | 17 | .1-.05 | ns |
| 0.8 vs 100 | < .001 | vhs | 20 | ∼ .01 | s |
| 0.8 vs 200 | < .001 | vhs | 16 | < .01 | hs |
| 4.0 vs 20.0 | .3-.2 | ns | 20 | ≧ .9 | ns |
| 4.0 vs 50.0 | .1-.05 | ns | 17 | .6 | ns |
| 4.0 vs 100 | < .001 | vhs | 20 | .3-.2 | ns |
| 4.0 vs 200 | < .001 | vhs | 15 | .01-.001 | hs |
| 20.0 vs 50.0 | ∼ .7 | ns | 17 | .6 | ns |
| 20.0 vs 100 | < .001 | vhs | 20 | .3 | ns |
| 20.0 vs 200 | < .001 | vhs | 15 | .01-.001 | hs |
| 50.0 vs 100 | < .001 | vhs | 17 | .7 | ns |
| 50.0 vs 200 | < .001 | vhs | 15 | .1 | ns |
| 100 vs 200 | .05-.02 | s | 15 | .05 | s |
ns, not significant at the .05 level; s, significant at the .05 level; hs, highly significant; vhs, very highly significant.
Based on data illustrated in Figure 2.