Routine coagulation studies from the propositus and the members of his family
| . | Propositus . | Sister . | Father . | Mother . | Control . |
|---|---|---|---|---|---|
| Prothrombin time (sec)* | >180 | >180 | 16.5 | 15.5 | 13 |
| Thrombin time (sec) | |||||
| Without CaCl2 | 300 | 380 | 30 | 30 | 20 |
| With CaCl2 | 300 | 380 | ND | ND | 17 |
| Reptilase time (sec) | Unclottable | Unclottable | ND | ND | 20 |
| Reptilase (×10) | Unclottable | Unclottable | ND | ND | 10 |
| Fibrinogen (g/L) | |||||
| Functional assay | 0.20 | 0.20 | 0.80 | 0.80 | 2 ñ 4 |
| Heat precipitation | 3.15 | 3.30 | 3.70 | 4.00 | 2 ñ4 |
| Immunologic assay | 3.05 | 3.02 | 4.00 | 4.40 | 2 ñ4 |
| Fibrinogen-related antigen in serum (μg/mL) | 20 | 20 | ND | ND | 20 |
| . | Propositus . | Sister . | Father . | Mother . | Control . |
|---|---|---|---|---|---|
| Prothrombin time (sec)* | >180 | >180 | 16.5 | 15.5 | 13 |
| Thrombin time (sec) | |||||
| Without CaCl2 | 300 | 380 | 30 | 30 | 20 |
| With CaCl2 | 300 | 380 | ND | ND | 17 |
| Reptilase time (sec) | Unclottable | Unclottable | ND | ND | 20 |
| Reptilase (×10) | Unclottable | Unclottable | ND | ND | 10 |
| Fibrinogen (g/L) | |||||
| Functional assay | 0.20 | 0.20 | 0.80 | 0.80 | 2 ñ 4 |
| Heat precipitation | 3.15 | 3.30 | 3.70 | 4.00 | 2 ñ4 |
| Immunologic assay | 3.05 | 3.02 | 4.00 | 4.40 | 2 ñ4 |
| Fibrinogen-related antigen in serum (μg/mL) | 20 | 20 | ND | ND | 20 |
For each member of the family, factors V, VII+X, and II were in the normal range. ND, not determined.