Categorized transcripts highly expressed or increased in LPS-stimulated monocytes
| Fold . | Tag sequences . | No. . | GenBank match (accession number) . | |
|---|---|---|---|---|
| Mono . | LPS . | |||
| Cytokines and cytokine receptors | ||||
| 128 | GGCACCTCAG | 0 | 128 | IL-6 (M14584) |
| 25 | AGACCACTGT | 0 | 25 | IL-1α (X02851) |
| 20 | CAATTTGTGT | 9 | 177 | IL-1β (K02770) |
| 15 | TAGCCCCCTG | 11 | 166 | TNF (M10988) |
| 16 | TGGATTTGGT | 0 | 16 | IL-7 receptor (M29696) |
| Chemokines | ||||
| CC | ||||
| 108 | GATAACACAT | 2 | 215 | MIP1β (J04130) |
| 19 | GAGGGTTTAG | 0 | 19 | LARC (D86955) |
| 18 | GCACCAAAGC | 66 | 1 195 | MIP1α (D00044) |
| 17 | GGCACAAAGG | 0 | 17 | TARC (D43767) |
| 13 | AACGGGGCCC | 0 | 13 | MDC (U83171) |
| 12 | AAAAATCGGC | 0 | 12 | RANTES (AA486072) |
| 7 | GTACTAGTGT | 0 | 7 | MCP-1 (M24545) |
| 6 | GATCATCAAG | 0 | 6 | MCP-2 (Y10802) |
| CXC | ||||
| 30 | ATAATAAAAG | 0 | 30 | MIP2β/GROγ (M36821) |
| 30 | TTGAAGCTTT | 1 | 30 | MIP2α/GROβ (M36820) |
| 12 | TTGAAACTTT | 0 | 12 | GROα (J03561) |
| 5 | TGGAAGCACT | 60 | 317 | IL-8 (Y00787) |
| Proteases and protease inhibitors | ||||
| 105 | CCCTTCTGTA | 0 | 105 | PAI-2 (Y00630) |
| 28 | TAAATCCCCA | 1 | 28 | MMP9/collagenase type IV (J05070) |
| 4 | TGGGTGAGCC | 24 | 112 | Cathepsin B (L16510) |
| 0.8 | TGCCTGCACC | 130 | 108 | Cystatin C (X05607) |
| Lipid metabolism | ||||
| 44 | TGGCCCCAGG | 4 | 177 | Apolipoprotein C-1 (NM001645) |
| 38 | CGACCCCACG | 4 | 152 | Apolipoprotein E (M12529) |
| 17 | AGAAGTGTCC | 1 | 17 | Lysosomal acid lipase A (Z31690) |
| Transcriptional factors | ||||
| 21 | GGAAGGGGAG | 1 | 21 | NF-κB p50 (X61498) |
| 10 | ATTATGGGCA | 0 | 10 | NF-κB p105 (M55643) |
| Iron homeostasis | ||||
| 2 | CCCTGGGTTC | 355 | 591 | Ferritin L chain (M11147) |
| 1 | TTGGGGTTTC | 471 | 534 | Ferritin H chain (M97164) |
| Antigen presentation | ||||
| 0.9 | GTTCACATTA | 230 | 203 | CD74, HLA-DR invariant chain p33 (X00497) |
| 1 | GTTGTGGTTA | 170 | 169 | β-2 microglobulin (AB021288) |
| 0.8 | GGGCATCTCT | 161 | 131 | HLA-DR α chain (V00523) |
| 0.6 | CTGACCTGTG | 220 | 122 | MHC class I (M28205) |
| 0.9 | GTGCGCTGAG | 108 | 96 | HLA class IC (X58536) |
| Fold . | Tag sequences . | No. . | GenBank match (accession number) . | |
|---|---|---|---|---|
| Mono . | LPS . | |||
| Cytokines and cytokine receptors | ||||
| 128 | GGCACCTCAG | 0 | 128 | IL-6 (M14584) |
| 25 | AGACCACTGT | 0 | 25 | IL-1α (X02851) |
| 20 | CAATTTGTGT | 9 | 177 | IL-1β (K02770) |
| 15 | TAGCCCCCTG | 11 | 166 | TNF (M10988) |
| 16 | TGGATTTGGT | 0 | 16 | IL-7 receptor (M29696) |
| Chemokines | ||||
| CC | ||||
| 108 | GATAACACAT | 2 | 215 | MIP1β (J04130) |
| 19 | GAGGGTTTAG | 0 | 19 | LARC (D86955) |
| 18 | GCACCAAAGC | 66 | 1 195 | MIP1α (D00044) |
| 17 | GGCACAAAGG | 0 | 17 | TARC (D43767) |
| 13 | AACGGGGCCC | 0 | 13 | MDC (U83171) |
| 12 | AAAAATCGGC | 0 | 12 | RANTES (AA486072) |
| 7 | GTACTAGTGT | 0 | 7 | MCP-1 (M24545) |
| 6 | GATCATCAAG | 0 | 6 | MCP-2 (Y10802) |
| CXC | ||||
| 30 | ATAATAAAAG | 0 | 30 | MIP2β/GROγ (M36821) |
| 30 | TTGAAGCTTT | 1 | 30 | MIP2α/GROβ (M36820) |
| 12 | TTGAAACTTT | 0 | 12 | GROα (J03561) |
| 5 | TGGAAGCACT | 60 | 317 | IL-8 (Y00787) |
| Proteases and protease inhibitors | ||||
| 105 | CCCTTCTGTA | 0 | 105 | PAI-2 (Y00630) |
| 28 | TAAATCCCCA | 1 | 28 | MMP9/collagenase type IV (J05070) |
| 4 | TGGGTGAGCC | 24 | 112 | Cathepsin B (L16510) |
| 0.8 | TGCCTGCACC | 130 | 108 | Cystatin C (X05607) |
| Lipid metabolism | ||||
| 44 | TGGCCCCAGG | 4 | 177 | Apolipoprotein C-1 (NM001645) |
| 38 | CGACCCCACG | 4 | 152 | Apolipoprotein E (M12529) |
| 17 | AGAAGTGTCC | 1 | 17 | Lysosomal acid lipase A (Z31690) |
| Transcriptional factors | ||||
| 21 | GGAAGGGGAG | 1 | 21 | NF-κB p50 (X61498) |
| 10 | ATTATGGGCA | 0 | 10 | NF-κB p105 (M55643) |
| Iron homeostasis | ||||
| 2 | CCCTGGGTTC | 355 | 591 | Ferritin L chain (M11147) |
| 1 | TTGGGGTTTC | 471 | 534 | Ferritin H chain (M97164) |
| Antigen presentation | ||||
| 0.9 | GTTCACATTA | 230 | 203 | CD74, HLA-DR invariant chain p33 (X00497) |
| 1 | GTTGTGGTTA | 170 | 169 | β-2 microglobulin (AB021288) |
| 0.8 | GGGCATCTCT | 161 | 131 | HLA-DR α chain (V00523) |
| 0.6 | CTGACCTGTG | 220 | 122 | MHC class I (M28205) |
| 0.9 | GTGCGCTGAG | 108 | 96 | HLA class IC (X58536) |
The tag sequence represents the 10-bp SAGE tag. The most probable GenBank matches are listed.
Each tag number was normalized using SAGE software by calculating the total tag number to 35 800.
No. indicates the number of times the tag was identified. Fold change in expression was calculated as described in Figure 1.
Mono and LPS indicate resting and LPS-stimulated monocytes, respectively.
More information on this table is available at our web site (http://www.prevent.m.u-tokyo.ac.jp/SAGE.html).