Prevalence of splenomegaly by hemoglobin type among the Dogon cases
| . | Hemoglobin type, No. cases (%) . | Total, No. cases (%) . | |||
|---|---|---|---|---|---|
| AA . | AC . | CC . | AS . | ||
| Uncomplicated malaria controls | 66 (21) | 11 (18) | 0 (0) | 3 (30) | 70 (18) |
| Severe malaria | 32 (52) | 2 (66) | 0 (0) | 2 (66) | 36 (54) |
| . | Hemoglobin type, No. cases (%) . | Total, No. cases (%) . | |||
|---|---|---|---|---|---|
| AA . | AC . | CC . | AS . | ||
| Uncomplicated malaria controls | 66 (21) | 11 (18) | 0 (0) | 3 (30) | 70 (18) |
| Severe malaria | 32 (52) | 2 (66) | 0 (0) | 2 (66) | 36 (54) |
In uncomplicated malaria control cases, 313 HbAA, 62 HbAC, 6 HbCC, and 10 HbAS cases were examined for splenomegaly. In the severe malaria cases, 61 HbAA, 3 HbAC, 0 HbCC, and 3 HbAS cases were examined for splenomegaly. The prevalence of splenomegaly was significantly more frequent in patients with severe malaria than in uncomplicated malaria controls (chi-square test, P<.001; OR 2.73; 95% CL, 1.54-5.31).