Age-matched comparison of severe malaria among urban Dogon cases
| . | Severe cases, No. . | Control cases, No. . | OR (CL) . | P . |
|---|---|---|---|---|
| Hemoglobin type | ||||
| AA | 44 | 76 | ||
| AC or CC | 2 | 16 | 0.22 (0.02-1.00) | .06 |
| AS | 2 | 4 | 1.00 (0.09-7.36) | .66 |
| Clinical features | ||||
| Total cases | 48 | 96 | ||
| Mean age, y (IQR) | 5.0 (2-4) | 5.0 (2-5) | ||
| Urban residence, No. cases (%) | 48 (100) | 96 (100) | ||
| Cerebral manifestations | 26 | 0 | ||
| Severe anemia (hct<15%) | 7 | 0 | ||
| Hyperparasitemia (Ep>5×105/μL) | 15 | 0 | ||
| Respiratory distress or shock | 2 | 0 | ||
| Severe prostration | 2 | 0 |
| . | Severe cases, No. . | Control cases, No. . | OR (CL) . | P . |
|---|---|---|---|---|
| Hemoglobin type | ||||
| AA | 44 | 76 | ||
| AC or CC | 2 | 16 | 0.22 (0.02-1.00) | .06 |
| AS | 2 | 4 | 1.00 (0.09-7.36) | .66 |
| Clinical features | ||||
| Total cases | 48 | 96 | ||
| Mean age, y (IQR) | 5.0 (2-4) | 5.0 (2-5) | ||
| Urban residence, No. cases (%) | 48 (100) | 96 (100) | ||
| Cerebral manifestations | 26 | 0 | ||
| Severe anemia (hct<15%) | 7 | 0 | ||
| Hyperparasitemia (Ep>5×105/μL) | 15 | 0 | ||
| Respiratory distress or shock | 2 | 0 | ||
| Severe prostration | 2 | 0 |
Each urban case of severe malaria among the Dogon ethnic group was randomly matched with two uncomplicated malaria control cases from within Bandiagara, Mali, that were in the same ethnic group and age group (0-2 years, 3-6 years, 7-15 years, or more than 16 years). The Mantel-Haenszel weighted summary OR with exact 95% CL are from comparison of the AC and CC versus AA and AS hemoglobin types, or of the AS versus non-AS hemoglobin types, between cases and controls after stratification by age.