Clinical and demographic characteristics of 59 patients with B-cell lymphoma
| Characteristics . | Number . | Percent . |
|---|---|---|
| Age (yr) | ||
| ≤60 | 49 | 83 |
| >60 | 10 | 17 |
| Gender | ||
| Male | 37 | 63 |
| Female | 22 | 37 |
| Stage of disease | ||
| I/II | 7 | 12 |
| III/IV | 52 | 88 |
| Histology* | ||
| Low-grade | 28 | 47 |
| Transformed low-grade | 14 | 24 |
| De novo intermediate/high-grade | 17 | 29 |
| Tumor burden >500 grams | ||
| Yes | 21 | 36 |
| No | 38 | 64 |
| Bone marrow involvement | ||
| None | 38 | 68 |
| 1%-25% | 17 | 29 |
| >25% | 1 | 2 |
| Lactate dehydrogenase (LDH) | ||
| Elevated | 30 | 51 |
| Normal/low | 29 | 49 |
| Prior bone marrow transplant | ||
| Yes | 14 | 24 |
| No | 45 | 76 |
| Number of prior therapies | ||
| 1-3 | 20 | 34 |
| ≥4 | 39 | 66 |
| Response to last therapy | ||
| No response | 28 | 48 |
| Response (PR + CR) | 30 | 52 |
| Characteristics . | Number . | Percent . |
|---|---|---|
| Age (yr) | ||
| ≤60 | 49 | 83 |
| >60 | 10 | 17 |
| Gender | ||
| Male | 37 | 63 |
| Female | 22 | 37 |
| Stage of disease | ||
| I/II | 7 | 12 |
| III/IV | 52 | 88 |
| Histology* | ||
| Low-grade | 28 | 47 |
| Transformed low-grade | 14 | 24 |
| De novo intermediate/high-grade | 17 | 29 |
| Tumor burden >500 grams | ||
| Yes | 21 | 36 |
| No | 38 | 64 |
| Bone marrow involvement | ||
| None | 38 | 68 |
| 1%-25% | 17 | 29 |
| >25% | 1 | 2 |
| Lactate dehydrogenase (LDH) | ||
| Elevated | 30 | 51 |
| Normal/low | 29 | 49 |
| Prior bone marrow transplant | ||
| Yes | 14 | 24 |
| No | 45 | 76 |
| Number of prior therapies | ||
| 1-3 | 20 | 34 |
| ≥4 | 39 | 66 |
| Response to last therapy | ||
| No response | 28 | 48 |
| Response (PR + CR) | 30 | 52 |
According to the International Working Formulation,35 of the 28 patients with low-grade non-Hodgkin lymphoma (NHL), 16 had follicular small-cleaved, 11 had follicular mixed small-cleaved and large cell, and 1 had small lymphocytic lymphoma. Of the 14 patients with transformed low-grade NHL, 8 had diffuse large cell, 2 had immunoblastic large cell, and 4 had follicular large cell. Of the 17 patients with intermediate- or high-grade lymphoma at diagnosis, 9 had diffuse large cell, 4 had mantle cell, 2 had diffuse mixed large and small cell, and 2 had immunoblastic large cell lymphoma. PR indicates partial response; CR, complete response.