Patient characteristics, preparative regimens and degree of ABO-incompatibility
| Parameter . | Donor type . | |
|---|---|---|
| Matched related . | Matched unrelated . | |
| Total no of patients | 921 | 755 |
| Gender (% male) | 57% | 56% |
| Age at transplant (y) | ||
| Median (range) | 35.3 (0.6-67.8) | 32.3 (0.5-56.3) |
| Diagnoses (no of patients [%]) | ||
| ALL | 97 (11) | 129 (17) |
| ANL | 211 (23) | 152 (20) |
| CML | 444 (48) | 381 (50) |
| HD | 22 (2) | 3 (1) |
| NHL | 65 (7) | 15 (2) |
| MDS | 82 (9) | 75 (10) |
| Acute GvHD* (no of patients [%]) | ||
| Grades 0-I | 491 (54) | 124 (17) |
| Grades II-IV | 427 (47) | 624 (83) |
| Preparative regimen† (no of patients [%]) | ||
| Cy/TBI | 506 (56) | 615 (81) |
| Bu/Cy | 256 (28) | 37 (5) |
| Other TBI-containing regimens | 114 (13) | 88 (12) |
| Other non-TBI-containing regimens | 35 (4) | 15 (2) |
| Antibody depletion (no of patients [%]) | ||
| Plasma exchange | 14 (2) | 146 (19) |
| Plasma absorption | 3 (0.3) | 1 (0.1) |
| ABO-compatible (no of patients [%]) | 625 (68) | 335 (44) |
| ABO-incompatible (no of patients [%]) | ||
| Major mismatch | 150 (16) | 164 (22) |
| Minor mismatch | 116 (13) | 183 (24) |
| Major/minor mismatch | 30 (3) | 73 (10) |
| Parameter . | Donor type . | |
|---|---|---|
| Matched related . | Matched unrelated . | |
| Total no of patients | 921 | 755 |
| Gender (% male) | 57% | 56% |
| Age at transplant (y) | ||
| Median (range) | 35.3 (0.6-67.8) | 32.3 (0.5-56.3) |
| Diagnoses (no of patients [%]) | ||
| ALL | 97 (11) | 129 (17) |
| ANL | 211 (23) | 152 (20) |
| CML | 444 (48) | 381 (50) |
| HD | 22 (2) | 3 (1) |
| NHL | 65 (7) | 15 (2) |
| MDS | 82 (9) | 75 (10) |
| Acute GvHD* (no of patients [%]) | ||
| Grades 0-I | 491 (54) | 124 (17) |
| Grades II-IV | 427 (47) | 624 (83) |
| Preparative regimen† (no of patients [%]) | ||
| Cy/TBI | 506 (56) | 615 (81) |
| Bu/Cy | 256 (28) | 37 (5) |
| Other TBI-containing regimens | 114 (13) | 88 (12) |
| Other non-TBI-containing regimens | 35 (4) | 15 (2) |
| Antibody depletion (no of patients [%]) | ||
| Plasma exchange | 14 (2) | 146 (19) |
| Plasma absorption | 3 (0.3) | 1 (0.1) |
| ABO-compatible (no of patients [%]) | 625 (68) | 335 (44) |
| ABO-incompatible (no of patients [%]) | ||
| Major mismatch | 150 (16) | 164 (22) |
| Minor mismatch | 116 (13) | 183 (24) |
| Major/minor mismatch | 30 (3) | 73 (10) |
In patients transplanted between 1983 and 1998 with marrow from HLA-matched related or HLA-matched unrelated donors.
GvHD, graft-versus-host disease, ALL, acute lymphoblastic leukemia; ANL, acute nonlymphocytic leukemia; CML, chronic myelogenous leukemia; HD, Hodgkin disease; NHL, non-Hodgkin disease; MDS, myelodysplastic syndrome; Cy/TBI, cytoxan/total body irradiation; TBI, total body irradiation.
Ten patients did not have an acute GvHD grade available at the time of analysis.
Ten patients were missing data pertaining to their preparative regimen.