Table 2.

Staging of gastric MALT lymphoma: comparison of different systems

Lugano Staging System for gastrointestinal lymphomas113TNM Staging System adapted for gastric lymphoma44Ann Arbor stage Tumor extension
Stage I  Confined to GI tract (single primary or multiple, noncontiguous)  T1 N0 M0 IE Mucosa, submucosa 
  T2 N0 M0 IE Muscularis propria 
  T3 N0 M0  IE Serosa 
Stage II  Extending into abdomen 
  II1 = local nodal involvement T1-3 N1 M0 IIE Perigastric lymph nodes 
  II2 = distant nodal involvement T1-3 N2 M0  IIE More distant regional lymph nodes  
Stage IIE Penetration of serosa to involve adjacent organs or tissues  T4 N0 M0  IE Invasion of adjacent structures  
Stage IV  Disseminated extranodal involvement or concomitant supra T1-4 N3 M0 IIIE Lymph nodes on both sides of the diaphragm/distant metas-  
   diaphragmatic nodal involvement  T1-4 N0-3 M1  IVE  tases (eg, bone marrow or additional extranodal sites) 
Lugano Staging System for gastrointestinal lymphomas113TNM Staging System adapted for gastric lymphoma44Ann Arbor stage Tumor extension
Stage I  Confined to GI tract (single primary or multiple, noncontiguous)  T1 N0 M0 IE Mucosa, submucosa 
  T2 N0 M0 IE Muscularis propria 
  T3 N0 M0  IE Serosa 
Stage II  Extending into abdomen 
  II1 = local nodal involvement T1-3 N1 M0 IIE Perigastric lymph nodes 
  II2 = distant nodal involvement T1-3 N2 M0  IIE More distant regional lymph nodes  
Stage IIE Penetration of serosa to involve adjacent organs or tissues  T4 N0 M0  IE Invasion of adjacent structures  
Stage IV  Disseminated extranodal involvement or concomitant supra T1-4 N3 M0 IIIE Lymph nodes on both sides of the diaphragm/distant metas-  
   diaphragmatic nodal involvement  T1-4 N0-3 M1  IVE  tases (eg, bone marrow or additional extranodal sites) 

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