Nine patients with severe chronic neutropenia receiving G-CSF therapy with clonal cytogenetic abnormalities but not malignant myeloid transformation
| Type of neutropenia . | Age, y sex . | G-CSF dose,4-150 μg/kg/d . | Duration of G-CSF at detection of abnormality, mo . | Prior cytogenetic evaluation . | Cytogenetic abnormality . | Treatment . | Length of follow-up after abnormality detected, mo . |
|---|---|---|---|---|---|---|---|
| Idiopathic | 67 F | 3.0 | 19.2 | normal | trisomy 8 | G-CSF discontinued | 74 |
| Congenital | 10 F | 3.5 | 48.5 | normal | inv(5)(q13q31) | G-CSF prn for infections | 65 |
| Cyclic | 11 F | 6.0 | 41.9 | normal | monosomy 21 inv(8) | G-CSF continued | 53 |
| Congenital | 11 F | 22.5 | 75.6 | normal | t(x;5)(q13;q35) | G-CSF continued | 37 |
| SDS | 12 M | 5.0 | 58.6 | normal | del(7)(q22q34) | G-CSF discontinued; BMT | 44 |
| SDS | 7 F | 16.0 | 70.3 | normal | monosomy 7 t(6;13)(q21;q32) | G-CSF continued; BMT | Expired 6 mo after diagnosis (sepsis post-BMT) |
| Idiopathic | 76 M | 2.4 | 75.5 | normal | del(11)(q23) | G-CSF continued; subsequent evaluation, normal karyotype | 26 |
| Congenital | 37 M | 2.4 | 90.8 | normal | monosomy 7 add(18)(p11) | G-CSF discontinued 2.5 mo after finding | 24 |
| Congenital | 8 F | 6.0 | 64.0 | normal | 5 q(−) | G-CSF continued | 2.5 |
| Type of neutropenia . | Age, y sex . | G-CSF dose,4-150 μg/kg/d . | Duration of G-CSF at detection of abnormality, mo . | Prior cytogenetic evaluation . | Cytogenetic abnormality . | Treatment . | Length of follow-up after abnormality detected, mo . |
|---|---|---|---|---|---|---|---|
| Idiopathic | 67 F | 3.0 | 19.2 | normal | trisomy 8 | G-CSF discontinued | 74 |
| Congenital | 10 F | 3.5 | 48.5 | normal | inv(5)(q13q31) | G-CSF prn for infections | 65 |
| Cyclic | 11 F | 6.0 | 41.9 | normal | monosomy 21 inv(8) | G-CSF continued | 53 |
| Congenital | 11 F | 22.5 | 75.6 | normal | t(x;5)(q13;q35) | G-CSF continued | 37 |
| SDS | 12 M | 5.0 | 58.6 | normal | del(7)(q22q34) | G-CSF discontinued; BMT | 44 |
| SDS | 7 F | 16.0 | 70.3 | normal | monosomy 7 t(6;13)(q21;q32) | G-CSF continued; BMT | Expired 6 mo after diagnosis (sepsis post-BMT) |
| Idiopathic | 76 M | 2.4 | 75.5 | normal | del(11)(q23) | G-CSF continued; subsequent evaluation, normal karyotype | 26 |
| Congenital | 37 M | 2.4 | 90.8 | normal | monosomy 7 add(18)(p11) | G-CSF discontinued 2.5 mo after finding | 24 |
| Congenital | 8 F | 6.0 | 64.0 | normal | 5 q(−) | G-CSF continued | 2.5 |
Indicates predominant dose given.