Summary of BCL-6 5′ regulatory region mutations in 10 cases of paired FCL and subsequent FCL or DLBCL specimens
| UPN . | Sample . | Date of biopsy . | Histology . | No. of confirmed mutations . | Type of mutation* . |
|---|---|---|---|---|---|
| IL105 | A | 2.1987 | FCL-1 | 3 | 186 (T > C)† |
| 586 (C > A) | |||||
| 671 (T > A)† | |||||
| B | 8.1990 | DLBCL | 3 | 350 (T > G) | |
| 586 (C > A) | |||||
| 671 (T > A)† | |||||
| IL114 | A | 4.1983 | FCL-DPSC | 0 | |
| B | 4.1985 | FCL-2 | 0 | ||
| C | 9.1992 | DLBCL | 6 | 182 (T > G)† | |
| 266 (T > C) | |||||
| 475 (T > C) | |||||
| 507 (C > T) | |||||
| 510 (C > A) | |||||
| 600 (C > A) | |||||
| IL115 | A | 3.1998 | FCL-1 | 1 | 110 (T > C) |
| B | 6.1999 | DLBCL | 3 | ▵▵T44† | |
| 110 (T > C) | |||||
| 188 (G > C) | |||||
| IL116 | A | 6.1987 | FCL-2 | 3 | 122 (G > A) |
| 480 (T > G)† | |||||
| 584 (C > T)† | |||||
| B | 2.1990 | DLBCL | 5 | 88 (G > C) | |
| 122 (G > A) | |||||
| 480 (T > G) | |||||
| 584 (C > T) | |||||
| 618 (G > A) | |||||
| IL117 | A | 7.1986 | FCL-1 | 0 | |
| B | 8.1991 | DLBCL | 0 | ||
| IL119 | A | 6.1985 | FCL-1 | 1 | 494 (T > A)† |
| B | 4.1993 | DLBCL | 0 | ||
| IL120 | A | 2.1989 | FCL-1 | 3 | ΔΔT44† |
| 329 (C > G)† | |||||
| 348 (C > T) | |||||
| B | 2.1992 | DLBCL | 5 | 104 (A > C) | |
| 180 (T > A) | |||||
| 348 (C > T) | |||||
| 507 (C > T)† | |||||
| 750 (C > G)† | |||||
| IL111 | A | 7.1988 | FCL-1 | 0 | |
| B | 9.1988 | FCL-1 | 0 | ||
| C | 1.1995 | FCL-1 | 0 | ||
| IL112 | A | 8.1987 | FCL-1 | 1 | 502 (G > A) |
| B | 4.1994 | FCL-1 | 1 | 502 (G > A) | |
| IL118 | A | 5.1990 | FCL-1 | 0 | |
| B | 4.1994 | FCL-1 | 0 |
| UPN . | Sample . | Date of biopsy . | Histology . | No. of confirmed mutations . | Type of mutation* . |
|---|---|---|---|---|---|
| IL105 | A | 2.1987 | FCL-1 | 3 | 186 (T > C)† |
| 586 (C > A) | |||||
| 671 (T > A)† | |||||
| B | 8.1990 | DLBCL | 3 | 350 (T > G) | |
| 586 (C > A) | |||||
| 671 (T > A)† | |||||
| IL114 | A | 4.1983 | FCL-DPSC | 0 | |
| B | 4.1985 | FCL-2 | 0 | ||
| C | 9.1992 | DLBCL | 6 | 182 (T > G)† | |
| 266 (T > C) | |||||
| 475 (T > C) | |||||
| 507 (C > T) | |||||
| 510 (C > A) | |||||
| 600 (C > A) | |||||
| IL115 | A | 3.1998 | FCL-1 | 1 | 110 (T > C) |
| B | 6.1999 | DLBCL | 3 | ▵▵T44† | |
| 110 (T > C) | |||||
| 188 (G > C) | |||||
| IL116 | A | 6.1987 | FCL-2 | 3 | 122 (G > A) |
| 480 (T > G)† | |||||
| 584 (C > T)† | |||||
| B | 2.1990 | DLBCL | 5 | 88 (G > C) | |
| 122 (G > A) | |||||
| 480 (T > G) | |||||
| 584 (C > T) | |||||
| 618 (G > A) | |||||
| IL117 | A | 7.1986 | FCL-1 | 0 | |
| B | 8.1991 | DLBCL | 0 | ||
| IL119 | A | 6.1985 | FCL-1 | 1 | 494 (T > A)† |
| B | 4.1993 | DLBCL | 0 | ||
| IL120 | A | 2.1989 | FCL-1 | 3 | ΔΔT44† |
| 329 (C > G)† | |||||
| 348 (C > T) | |||||
| B | 2.1992 | DLBCL | 5 | 104 (A > C) | |
| 180 (T > A) | |||||
| 348 (C > T) | |||||
| 507 (C > T)† | |||||
| 750 (C > G)† | |||||
| IL111 | A | 7.1988 | FCL-1 | 0 | |
| B | 9.1988 | FCL-1 | 0 | ||
| C | 1.1995 | FCL-1 | 0 | ||
| IL112 | A | 8.1987 | FCL-1 | 1 | 502 (G > A) |
| B | 4.1994 | FCL-1 | 1 | 502 (G > A) | |
| IL118 | A | 5.1990 | FCL-1 | 0 | |
| B | 4.1994 | FCL-1 | 0 |
FCL, follicle center lymphoma; DLBCL, diffuse large B-cell lymphoma; DPSC, diffuse predominantly small cell.
Mutations in bold represent new mutations observed in transformed DLBCL specimens but not in the initial FCL specimens.
Ongoing mutations present in some but not all molecular clones representing 1 allele.